Computed tomographic airway morphology after targeted lung denervation treatment in COPD - 30/12/22
Doi : 10.1016/j.rmed.2022.107059
Jorine E. Hartman a, b, ⁎ 
, Felix J.F. Herth c, Pallav Shah d, e, f, Christophe Pison g, h, i, Arschang Valipour j, Dirk-Jan Slebos a, b
, Felix J.F. Herth c, Pallav Shah d, e, f, Christophe Pison g, h, i, Arschang Valipour j, Dirk-Jan Slebos a, bAIRFLOW-2 Study Group
Arschang Valipour, Christine Abele, Irene Firlinger, Kiran Kothakuzhakal, Marina Duller, Bernd Lamprecht, Roland Kropfmueller, Kornelia Holzmann, Sandra Rathmeier, Ralf Hubner, Leonore Erdmann, Bettina Temmesfeld-Wollbrück, Christoph Ruwwe Glösenkamp, Wolfgang Gesierich, Frank Reichenberger, Christa Niehaus, Felix Herth, Ralf Eberhardt, Daniela Gompelmann, Brigitte Rump, Kaid Darwiche, Stephan Eisenmann, Ulrike Kaiser, Birte Schwarz, Ulrike Sampel, Christian Schumann, Robert Kaiser, Kathryn Schumann-Stoiber, Dirk Skowasch, Sabine Ring, Christophe Pison, Amandine Briault, Francois Arbib, Marie Jondot, Thierry Perez, Clement Fournier, Regis Matran, Michele Catto, Nathalie Bautin, Virginie De Broucker, Marie Willemin, Anne Prevotat, Ludivine Wemeau, Alice Gicquello, Morgane Foulon, Hasna Camara, Gaetan Deslee, Herve Vallerand, Sandra Dury, Delphine Gras, Margaux Bonnaire-Verdier, Romain Kessler, Sandrine Hirschi, Michele Porzio, Tristan Degot, Mathieu Canuet, Armelle Schuller, Julien Stauder, Sahra Ali Azouaou, Armelle Marceau, Hervé Mal, Yolande Costa, Pallav L. Shah, Justin Garner, Karthi Srikanthan, Cielito Caneja, John Thornton, Dirk-Jan Slebos, Nick Ten Hacken, Jorine Hartman, Karin Klooster, Sonja Augustijn, Peter Bonta, Jouke Annema, Marianne van de Pol, Annika Goorsenberg
a Department of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands
b Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands
c Department of Pneumology and Critical Care Medicine, Thoraxklinik and Translational Lung Research Center, University of Heidelberg, Germany
d Royal Brompton Hospital, London, United Kingdom
e Chelsea & Westminster Hospital, London, United Kingdom
f National Heart and Lung Institute, Imperial College London, London, United Kingdom
g Service Hospitalier Universitaire de Pneumologie Physiologie, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France
h Centre de Pneumologie Henri Bazire, Saint Julien de Ratz, France
i Département Universitaire des Patients Grenoble Alpes, Faculté de Médecine Pharmacie, Université Grenoble Alpes, La Tronche, France
j Department of Respiratory and Critical Care Medicine, Vienna Health Care Group, Klinik Floridsdorf, Vienna, Austria
∗Corresponding author. Department of Pulmonary diseases AA11, University Medical Center Groningen, PO Box 30001, 9700 RB, Groningen, the Netherlands.Department of Pulmonary diseases AA11University Medical Center GroningenPO Box 300019700 RBGroningenthe Netherlands
Abstract |
This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV1. Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes.
Le texte complet de cet article est disponible en PDF.Highlights |
• | So far changes in airway CT parameters were not investigated after targeted lung denervation (TLD). |
• | No significant changes in CT parameters were found after TLD treatment compared to a control group. |
• | An improvement in air trapping was significantly associated with an improvement in residual volume. |
• | Improvements in Pi10 and airway lumen were significantly associated with improvements in RV and FEV1. |
• | Improving airway characteristics could lead to less air trapping and improvements in clinical outcomes. |
Plan
© 2022
The Author(s). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 206
Article 107059- janvier 2023 Retour au numéro
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