Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine - 13/01/23

Doi : 10.1016/j.biopha.2022.114104

Nermeen Yosri ^a, Sultan M. Alsharif ^b, Jianbo Xiao ^c, Syed G. Musharraf ^d, Chao Zhao ^e, Aamer Saeed ^f, Ruichang Gao ^g, Noha S. Said ^h, Alessandro Di Minno ^i,^j, Maria Daglia ^i,^k, Zhiming Guo ^g, Shaden A.M. Khalifa ^l, Hesham R. El-Seedi ^h,^k,^m,^n,^⁎
^a Chemistry Department of Medicinal and Aromatic Plants, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef 62514, Egypt
^b Biology Department, Faculty of Science, Taibah University, Al Madinah 887, Saudi Arabia
^c Department of Analytical Chemistry and Food Science, Faculty of Food Science and Technology, University of Vigo, Vigo, Spain
^d H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
^e College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China
^f Chemistry Department, Quaid-i-Azam University, Islamabad 45320, Pakistan
^g School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
^h Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom 32512, Egypt
ⁱ Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy
^j CEINGE-Biotecnologie Avanzate, Naples 80131, Italy
^k International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China
^l Department of Molecular Biosciences, Stockholm University, The Wenner-GrenInstitute, SE-106 91 Stockholm, Sweden
^m Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Box 591, SE 751 24 Uppsala, Sweden
ⁿ International Joint Research Laboratory of Intelligent Agriculture and Agri-products Processing (Jiangsu Education Department), Zhenjiang 212013, China

^⁎Corresponding author at: Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical Centre, Box 591, SE 751 24 Uppsala, Sweden.Pharmacognosy Group, Department of Pharmaceutical Biosciences, Uppsala University, Biomedical CentreBox 591UppsalaSE 751 24Sweden

Abstract

Arctium lappa L. is a medicinal edible homologous plant, commonly known as burdock or bardana, which belongs to the Asteraceae family. It is widely distributed throughout Northern Asia, Europe, and North America and has been utilized for hundreds of years. The roots, fruits, seeds, and leaves of A. lappa have been extensively used in traditional Chinese Medicine (TCM). A. lappa has attracted a great deal of attention due to its possession of highly recognized bioactive metabolites with significant therapeutic potential. Numerous pharmacological effects have been demonstrated in vitro and in vivo by A. lappa and its bioactive metabolites, including antimicrobial, anti-obesity, antioxidant, anticancer, anti-inflammatory, anti-diabetic, anti-allergic, antiviral, gastroprotective, hepatoprotective, and neuroprotective activities. Additionally, A. lappa has demonstrated considerable clinical efficacies and valuable applications in nanomedicine. Collectively, this review covers the properties of A. lappa and its bioactive metabolites, ethnopharmacology aspects, pharmacological effects, clinical trials, and applications in the field of nanomedicine. Hence, a significant attention should be paid to clinical trials and industrial applications of this plant with particular emphasis, on drug discovery and nanotechnology.

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Highlights

•	Since ancient times, A. lappa L. has highly impact in traditional medicine.
•	lappa L has attracted a great attention due to its highly bioactive metabolites.
•	lappa L. has demonstrated considerable several clinical efficacies.
•	lappa L. constitutes have unique mechanism of action in nanomedical application.

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Abbreviations : Covid-19, TCM, EMA, DCMQA, DPPH, H₂O_2,, NMDA, JNK, ERK 1/2, MAPKs, AMPK), mTOR, miRNA, GSK-3β, AKT, ERK1/2, ABTS, Nrf2/HO-1, SREBP-1, IL-6, (IL-1β, TNF-α, NLRP3, ATPase, mROS, PI3K/AKT, NF-κB, COX-2, MAPK, AMPK, MDA, NO, SOD, GSH, NADPH, GSH-Px, AR, VEGF, EGF, NGF, FGF-β, PDGF-BB, GST-P), PNLs, GLP‐1, HOMA‐IR, UCP1, PGC1α, PPARγ, C/EBPα), SREBP-1, SCD-1, NPs, XRD, TEM, FTIR, SEM, XPS, AFM, UV, EDX, MHA, PG, scCO2, EtOH, AcOEt, LDH, MMP, ROS, OGD/R, MQA, CNQX, b.w., ASALP, AST, ALT, ALP, LPS, PNG, TNBS, DMEM, IκBα, DAI, DSS, MPO, PBS, PCV2, CHOL, TC, FBG, Homa-IR, HDL-C, LDL-C, PBG, HbA1c, GK, OGTT, IPGTT, SGPT, DMSO

Keywords : Arctium lappa L., Folk medicine, Bioactive constituents, Preclinical trials, Clinical trials, Nanomedicine

Plan

Introduction

Taxonomy, botanical and ethnopharmacological aspects

Phytochemical constituents

Pharmacological activities

In vitro studies

In vivo studies

Clinical studies

Applications in nanomedicine

Conclusion and future perspectives

Funding

CRediT authorship contribution statement

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Vol 158

Article 114104- février 2023 Retour au numéro

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Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine - 13/01/23

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