Cisplatin-loaded gold nanoshells mediate chemo-photothermal therapy against primary and distal lung cancers growth - 13/01/23
Abstract |
Lung cancer is the most common cause of cancer mortality worldwide. The advances in surgery, radiotherapy, chemotherapeutic and immunotherapeutic drugs have progressed in the past decades, but the prognosis of lung cancer is still poor. In this study, we developed cisplatin (CDDP)-loaded human serum albumin (HSA)-based gold nanoshells (HCP@GNSs) for synergistic chemo-photothermal therapy (chemo-PTT). The HCP@GNSs not only acted as drug nanocarriers for chemotherapy but also serve as a superior mediator for PTT, which could exhibit a temperature increase upon a near infrared (NIR) laser exposure that was sufficient for photothermal ablation. HCP@GNSs were highly biocompatible and hemocompatible nanocarriers, while the synergistic chemo-PTT resulting from HCP@GNSs plus NIR exposure displayed stronger cytotoxicity effect than HCP@GNSs or PTT alone, especially at a low CDDP concentration. In vivo analysis demonstrated that HCP@GNSs-mediated chemo-PTT increased necrosis in tumors to achieve a high tumor clearance rate with no adverse side effects. Moreover, HCP@GNSs-medicated chemo-PTT induced the recruitment of dendritic cells, B-cells, and natural killer T-cells in distal tumors to inhibit the growth of the tumors. Therefore, the CDDP-loaded HCP@GNSs may be a potential nanomedicine candidate for curative lung cancer treatment in the future.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | CDDP can be successfully complexed with HSA to increase its biodistribution and reduce nephrotoxicity and cytotoxicity. |
• | GNSs with branched surface structures can be formed on HCP NPs by adding chloroauric acid solution and L-ascorbic acid. |
• | CDDP-loaded chemotherapeutic nanomedicine acts synergistically with PTT to provide an advanced anticancer effect. |
• | The HCP@GNSs plus NIR irradiation can enhance recruitments of B-cells, DCs, and NKT cells against distal tumor growth. |
Abbreviations : PTT, GNSs, NIR, NPs, CDDP, HSA, chemo-PTT, HCP NPs, HP NPs, HCP@GNSs, HP@GNSs, TEM, XRD, TGA, EE, OD, DCs, NK cells, NKT cells
Keywords : Combination therapy, Chemotherapy, Photothermal therapy, Human serum albumin, Cisplatin, Gold nanoshell
Plan
Vol 158
Article 114146- février 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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