Correlation between antibiotic use and antibiotic resistance: A multicenter study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system in Hokkaido, Japan - 20/01/23
Doi : 10.1016/j.ajic.2022.05.025
Keisuke Kagami, PhD a, b, ⁎ 
, Nobuhisa Ishiguro, MD, PhD b, Sumio Iwasaki, BS b, c, Takayuki Usami, BS b, c, Tatsuya Fukumoto, PhD b, c, Kasumi Hayasaka b, c, Reiko Oyamada b, Tsubasa Watanabe b, Sho Nakakubo, MD, PhD b, d, Yusuke Niinuma, BS a, b, Takashi Hagino, BS e, Yoshifumi Abe, MS e, Ikuya Fujimoto, MS f, Hideki Maekawa, BS g, Ryo Fujibayashi, BS g, Satoshi Fuke, MD, PhD h, i, Kuniko Asahi i, j, Shuichi Ota, MD, PhD k, l, Tatsuya Nagakura, BS l, Toshinari Okubo, MS m, Hideomi Asanuma, MD, PhD n, Toshihiro Ito, MD o, Sho Okano, BS p, Erika Komatsu, BS q, Kota Sasaki, BS r, Kei Hashimoto, BS s, Kazutoshi Washiya, BS s, Yumiko Kato t, Katsunori Kusumi u, Yasufumi Asai, MD, PhD v, Yuichi Saito, BS w, Yoshiyuki Sakai, MD, PhD x, Minoru Sakurada, BS y, Yuji Sakimoto, BS z, aa, Yukari Ichikawa, MS bb, Takahiro Kinebuchi, BS cc, Dai Kondo, BS dd, Syuhei Kanno, BS ee, ff, Minoru Kobayashi ff, Kagami Hirabayashi, MD, PhD gg, hh, Shinako Saitou hh, ii, Katsuhiko Saito, PhD jj, Yuuki Ebina, BS kk, Yuusuke Koshizaki ll, Makoto Chiba, MS mm, Atsushi Yasuda nn, Toshiya Sato, MD, PhD oo, pp, Atsuo Togashi, MD, PhD oo, pp, Takashi Abe qq, Takahiro Fujita, MD, PhD, MPH rr, Kengo Umehara, MS ss, Masaru Amishima, MD, PhD tt, Nobuo Murakami, MD, PhD uu, vv, Tetsuya Yagi, MD, PhD ww, Shuhei Fujimoto, MD, PhD xx, Taichi Tajima, MPH yy, Mitsuru Sugawara, PhD a, zz, Yoh Takekuma, PhD a
, Nobuhisa Ishiguro, MD, PhD b, Sumio Iwasaki, BS b, c, Takayuki Usami, BS b, c, Tatsuya Fukumoto, PhD b, c, Kasumi Hayasaka b, c, Reiko Oyamada b, Tsubasa Watanabe b, Sho Nakakubo, MD, PhD b, d, Yusuke Niinuma, BS a, b, Takashi Hagino, BS e, Yoshifumi Abe, MS e, Ikuya Fujimoto, MS f, Hideki Maekawa, BS g, Ryo Fujibayashi, BS g, Satoshi Fuke, MD, PhD h, i, Kuniko Asahi i, j, Shuichi Ota, MD, PhD k, l, Tatsuya Nagakura, BS l, Toshinari Okubo, MS m, Hideomi Asanuma, MD, PhD n, Toshihiro Ito, MD o, Sho Okano, BS p, Erika Komatsu, BS q, Kota Sasaki, BS r, Kei Hashimoto, BS s, Kazutoshi Washiya, BS s, Yumiko Kato t, Katsunori Kusumi u, Yasufumi Asai, MD, PhD v, Yuichi Saito, BS w, Yoshiyuki Sakai, MD, PhD x, Minoru Sakurada, BS y, Yuji Sakimoto, BS z, aa, Yukari Ichikawa, MS bb, Takahiro Kinebuchi, BS cc, Dai Kondo, BS dd, Syuhei Kanno, BS ee, ff, Minoru Kobayashi ff, Kagami Hirabayashi, MD, PhD gg, hh, Shinako Saitou hh, ii, Katsuhiko Saito, PhD jj, Yuuki Ebina, BS kk, Yuusuke Koshizaki ll, Makoto Chiba, MS mm, Atsushi Yasuda nn, Toshiya Sato, MD, PhD oo, pp, Atsuo Togashi, MD, PhD oo, pp, Takashi Abe qq, Takahiro Fujita, MD, PhD, MPH rr, Kengo Umehara, MS ss, Masaru Amishima, MD, PhD tt, Nobuo Murakami, MD, PhD uu, vv, Tetsuya Yagi, MD, PhD ww, Shuhei Fujimoto, MD, PhD xx, Taichi Tajima, MPH yy, Mitsuru Sugawara, PhD a, zz, Yoh Takekuma, PhD a a Department of Pharmacy, Hokkaido University Hospital, Kita-ku, Sapporo, Hokkaido, Japan
b Department of Infection Control and Prevention, Hokkaido University Hospital, Kita-ku, Sapporo, Hokkaido, Japan
c Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Kita-ku, Sapporo, Hokkaido, Japan
d Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Kita-ku, Sapporo, Hokkaido, Japan
e Infection Control Room, NTT Medical Center Sapporo, Chuo-ku, Sapporo, Hokkaido, Japan
f Department of Pharmacy, Kitasapporo Hospital, Kita-ku, Sapporo, Hokkaido, Japan
g Department of Pharmacy, Hokkaido Gastroenterology Hospital, Higashi-ku, Sapporo, Hokkaido, Japan
h Department of Respiratory Medicine, KKR Sapporo Medical Center, Toyohira-ku, Sapporo, Hokkaido, Japan
i Department of Infection Control and Prevention, KKR Sapporo Medical Center, Toyohira-ku, Sapporo, Hokkaido, Japan
j Department of Laboratory Medicine, KKR Sapporo Medical Center, Toyohira-ku, Sapporo, Hokkaido, Japan
k Department of Hematology, Sapporo Hokuyu Hospital, Shiroishi-ku, Sapporo, Hokkaido, Japan
l Department of Infection Control and Prevention, Sapporo Hokuyu Hospital, Shiroishi-ku, Sapporo, Hokkaido, Japan
m Department of Pharmacy, IMS Sapporo Internal Medicine Rehabilitation Hospital, Teine-ku, Sapporo, Hokkaido, Japan
n Department of Neonatology, Hokkaido Medical Center for Child Health and Rehabilitation, Teine-ku, Sapporo, Hokkaido, Japan
o Department of Cardiology, Sapporo Teishinkai Hospital, Higashi-ku, Sapporo, Hokkaido, Japan
p Department of Pharmacy, Sapporo Teishinkai Hospital, Higashi-ku, Sapporo, Hokkaido, Japan
q Department of Pharmacy, Ebetsu City Hospital, Ebetsu, Hokkaido, Japan
r Department of Clinical Laboratory, Ebetsu City Hospital, Ebetsu, Hokkaido, Japan
s Department of Pharmacy, Hakodate Goryoukaku Hospital, Hakodate, Hokkaido, Japan
t Department of Infection Control and Prevention, Hakodate Central General Hospital, Hakodate, Hokkaido, Japan
u Department of Pharmacy, Hakodate Central General Hospital, Hakodate, Hokkaido, Japan
v Department of Cardiology, Hakodate Shintoshi Hospital, Hakodate, Hokkaido, Japan
w Department of Pharmacy, Hakodate Shintoshi Hospital, Hakodate, Hokkaido, Japan
x Department of Pediatrics, Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan
y Department of Pharmacy, Hakodate Municipal Hospital, Hakodate, Hokkaido, Japan
z Department of Pharmacy, Yakumo General Hospital, Yakumo Town, Futami-gun, Hokkaido, Japan
aa Infection Control Room, Yakumo General Hospital, Yakumo Town, Futami-gun, Hokkaido, Japan
bb Infection Control Management, Asahikawa Red Cross Hospital, Asahikawa, Hokkaido, Japan
cc Department of Laboratory Medicine, Social Welfare Corporation Hokkaido Social Work Association Furano Hospital, Furano, Hokkaido, Japan
dd Department of Pharmacy, Social Welfare Corporation Hokkaido Social Work Association Furano Hospital, Furano, Hokkaido, Japan
ee Department of Pharmacy, Oji General Hospital, Tomakomai, Hokkaido, Japan
ff Infection Control Room, Oji General Hospital, Tomakomai, Hokkaido Japan
gg Department of Cardiologists, Tomakomai City Hospital, Tomakomai, Hokkaido, Japan
hh Department of Infection Control and Prevention, Tomakomai City Hospital, Tomakomai, Hokkaido, Japan
ii Department of Infection Prevention and Control Certified Nurse, Tomakomai City Hospital, Tomakomai, Hokkaido, Japan
jj Department of Pharmacy, Nemuro City Hospital, Nemuro, Hokkaido, Japan
kk Department of Pharmacy, Obihiro Kosei General Hospital, Obihiro, Hokkaido, Japan
ll Department of Clinical Laboratory Technology, Obihiro Kosei General Hospital, Obihiro, Hokkaido, Japan
mm Department of Pharmacy, Kitami Red Cross Hospital, Kitami, Hokkaido, Japan
nn Department of Clinical Laboratory, Kitami Red Cross Hospital, Kitami, Hokkaido, Japan
oo Department of Pediatrics, Iwamizawa Municipal General Hospital, Iwamizawa, Hokkaido, Japan
pp Department of Infection Prevention Office, Iwamizawa Municipal General Hospital, Iwamizawa, Hokkaido, Japan
qq Department of Laboratory Medicine, Takikawa Municipal Hospital, Takikawa, Hokkaido, Japan
rr Department of Infectious Diseases, National Hospital Organization Hokkaido Cancer Center, Shiroishi-ku, Sapporo, Hokkaido, Japan
ss Department of Pharmacy, National Hospital Organization Hokkaido Cancer Center, Shiroishi-ku, Sapporo, Hokkaido, Japan
tt Office for Infection Control and Prevention, NHO Hokkaido Medical Center, Nishi-ku, Sapporo, Hokkaido, Japan
uu Center for Regional Medicine, Gifu University School of Medicine, Yanagido, Gifu, Japan
vv Gifu General Healthcheckup Centre, Hikie, Gifu, Japan
ww Department of Infectious Diseases, Nagoya University Hospital, Showa-ku, Nagoya, Japan
xx Department of Bacteriology and Bacterial Infection, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa, Japan
yy AMR Clinical Reference Center, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan.
zz Laboratory of Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Hokkaido, Japan
⁎Address correspondence to Keisuke Kagami, PhD, Department of Pharmacy, Hokkaido University Hospital; Kita-14-jo, Nishi-5-chome, Kita-ku, Sapporo 060-8648, Japan.Department of PharmacyHokkaido University HospitalKita-14-jo, Nishi-5-chomeKita-kuSapporo060-8648Japan
Highlights |
• | The J-SIPHE system enabled multicenter analysis of antibiotic use and resistance. |
• | Carbapenem use correlated with carbapenem-resistant P. aeruginosa occurrence. |
• | Quinolone use correlated with fluoroquinolone-resistant E. coli occurrence. |
Abstract |
Background |
The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures in participating medical institutions nationwide and is intended to be used for promotion of AMR measures in participating facilities and their communities. This multicenter study aimed to determine the usefulness of the J-SIPHE system for evaluating the correlation between antibiotic use and antibiotic resistance in Hokkaido, Japan.
Methods |
Data on antibiotic use and detection rate of major resistant Gram-negative bacteria at 19 hospitals in 2020 were collected from the J-SIPHE system, and data correlations were analyzed using JMP Pro.
Results |
The detection rate of carbapenem-resistant Pseudomonas aeruginosa was significantly positively correlated with carbapenem use (Spearman's ρ = 0.551; P = .015). There were significant positive correlations between the detection rate of fluoroquinolone-resistant Escherichia coli and the use of piperacillin/tazobactam, carbapenems, and quinolones [ρ = 0.518 (P = .023), ρ = 0.76 (P < .001), and ρ = 0.502 (P = .029), respectively].
Conclusions |
This is the first multicenter study to investigate the correlation between antibiotic use and antibiotic resistance using the J-SIPHE system. The results suggest that using this system may be beneficial for promoting AMR measures.
Le texte complet de cet article est disponible en PDF.Key Words : AMR, Antimicrobial resistance, Antimicrobial stewardship, Carbapenems, Quinolones
Plan
| Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. |
|
| Conflicts of interest: All authors have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
© 2022
Association for Professionals in Infection Control and Epidemiology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 51 - N° 2
P. 163-171 - février 2023 Retour au numéro
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