Cannabidiol inhibits lung proliferation in monocrotaline-induced pulmonary hypertension in rats - 03/02/23
, Marta Baranowska-Kuczko a, b, Irena Kasacka c, Hanna Kozłowska aAbstract |
Cannabidiol (CBD) is a safe and well-tolerated plant-derived drug with anti-proliferative properties. Pulmonary hypertension (PH) is a rapidly progressive and still incurable disease. CBD diminishes monocrotaline (MCT)-induced PH, including reduced right ventricular systolic pressure, pulmonary vascular hypertrophy, and right ventricular remodeling. The aim of our study was to investigate the effect of chronic administration of CBD (10 mg/kg once daily for 21 days) on selected remodeling parameters in the lung of MCT-induced PH rats. In MCT-induced PH, we found an increase in profibrotic parameters, e.g., transforming growth factor β1 (TGF-β1), galectin-3 (Gal-3), procollagen I, collagen I, C-propeptide, matrix metalloproteinase 9 (MMP-9) and an increased number of mast cells. In our study, we observed that the TGF-β1, Gal-3, procollagen I, collagen I, C-propeptide, and mast cell levels in lung tissue were decreased after CBD administration to MCT-treated rats. In summary, CBD treatment has an anti-proliferative effect on MCT-induced PH. Given the beneficial multidirectional effects of CBD on PH, we believe that CBD can be used as an adjuvant PH therapy, but this argument needs to be confirmed by clinical trials.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The TGF-β1 pathway is involved in the lung fibrosis process. |
• | CBD has antiproliferative effect in lungs. |
• | CBD alleviates the lung remodeling in the PH rats by inhibiting TGF-β1 pathway. |
• | CBD may be used in the future as an adjuvant therapy in the treatment of PH. |
Abbreviations : CBD, CB2-R, CTR, i.p., Gal-3, MCT, MMP-9, PPARγ, PH, RV, RVSP, TGF-β1, TRPV4, s.c.
Keywords : Pulmonary hypertension, Cannabidiol, Monocrotaline, Animal model, Fibrosis, Lung fibrosis
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Vol 159
Article 114234- mars 2023 Retour au numéro
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