Research progress of traditional Chinese medicine compound "Xiaochaihu Decoction" in the treatment of depression - 03/02/23
, Mingqi Qiao a, ⁎ Abstract |
Depression is a common psychiatric disorder under the category of depression syndrome in Traditional Chinese Medicine (TCM) theory. Meanwhile, Xiaochaihu Decoction is a classical TCM formulation regulating Qi, resolving and dissipating stagnation. Clinically, the formulation has long been adopted to treat Shaoyang stagnation syndrome for depression syndrome. In this review, potential targets of action and the corresponding pathways of Xiaochaihu Decoction are explored for depression treatment via network pharmacology. The article also systematically summarizes the active components and pharmacological mechanisms of seven Chinese herbal medicine components in Xiaochaihu Decoction and guides the future study direction of Xiaochaihu Decoction, which may serve a promising treatment for depression.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Therapeutic effect of Xiaochaihu Decoction is based on multiple components, targets and pathways. |
• | Anti-inflammatory, neuron-protective and regulation of the HPA axis are key to the action of Xiaochaihu Decoction. |
• | The target of action of Xiaochaihu Decoction is predicted by network pharmacology approach. |
• | Xiaochaihu Decoction is promising in the treatment of depressive disorders. |
Abbreviation : NF-κB, IL-10, TGF-β, Arg-1, IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, DCX, BRDU, iNOS, COX-2, mBDNF, BDNF, CREB, PPARγ, AChE, DA, NE, 5-HT, GABA, Ach, PRRT2, mGluR5, NMDAR, mTOR, SYP, Bcl-2, TrkB, ERK, MAPK, AKT, PI3K, ACHT, CORT, SOD, CAT, T-AOC, HO-1, GSH-px, Nrf2, MDA, LDH, NO, NOX-2, LPO, XCHT, proBDNF, GSK3β, 5-HIAA, GFAP, PFC, GR, AR, NLRP3, GC, HPA, TCM, SSD, MePD, DG, HPG, MAO, MGB, LQ, SGZ, E2, P, Aβ, AD, HPLC
Keywords : Xiaochaihu Decoction, Depression, Depression syndrome, Active ingredients, Pharmacological action
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Vol 159
Article 114249- mars 2023 Retour au numéro
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