Clinical accuracy of SARS-CoV-2 rapid antigen testing in screening children and adolescents - 28/02/23

Doi : 10.1016/j.jinf.2022.12.017

Manuel Krone ^a,^b,^{^{1
These authors contributed equally to this work.},}^⁎ , Isabell Wagenhäuser ^a,^c,^{^{1
These authors contributed equally to this work.}}, Kerstin Knies ^d, Daniela Hofmann ^d, Geraldine Engels ^e, Regina Taurines ^f, Miriam McDonogh ^g, Sven Flemming ^h, Thomas Meyer ^h, Hartmut Böhm ⁱ, Agmal Scherzad ^j, Michael Eisenmann ^a, Vera Rauschenberger ^a,^b, Alexander Gabel ^a, Nils Petri ^c, Julia Reusch ^a,^c, Johannes Forster ^b, Benedikt Weißbrich ^d, Lars Dölken ^d, Oliver Kurzai ^b,^k, Ulrich Vogel ^a,^b,^{^{2
Ulrich Vogel passed away on the 4th of October 2022 during manuscript drafting. We miss him as an enthusiastic collegeand friend who showed a great dedication to his work, family, and friends.}}, Christoph Härtel ^e, Johannes Liese ^e,^{^{1
These authors contributed equally to this work.}}, Oliver Andres ^e,^{^{1
These authors contributed equally to this work.}}
^a Infection Control and Antimicrobial Stewardship Unit, University Hospital Wuerzburg, Josef-Schneider-Str. 2, Wuerzburg 97080, Germany
^b Institute for Hygiene and Microbiology, University of Wuerzburg, Josef-Schneider-Str. 2, Wuerzburg 97080, Germany
^c Department of Internal Medicine I, University Hospital Wuerzburg, Oberdürrbacher Str. 6, Wuerzburg 97080, Germany
^d Institute for Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, Würzburg 97078, Germany
^e Department of Paediatrics, University Hospital Wuerzburg, Wuerzburg, Germany
^f Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Margarete-Höppel-Platz 1, Würzburg 97080, Germany
^g Department of Orthopaedic Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Wuerzburg, Oberdürrbacher Str. 6, Wuerzburg 97080, Germany
^h Department of General, Visceral, Transplantation, Vascular and Paediatric Surgery, University Hospital Wuerzburg, Oberdürrbacher Str. 6, Wuerzburg 97080, Germany
ⁱ Department of Oral and Maxillofacial Surgery, University Hospital Wuerzburg, Pleicherwall 2, Wuerzburg 97070, Germany
^j Department of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Wuerzburg, Josef-Schneider-Str. 11, Wuerzburg 97080, Germany
^k Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knoell-Institute, Beutenbergstraße 13, Jena 07745, Germany

^⁎Corresponding author at: Institute for Hygiene and Microbiology, University of Wuerzburg, Josef-Schneider-Str. 2 / E1, Wuerzburg 97080, Germany.Institute for Hygiene and MicrobiologyUniversity of WuerzburgJosef-Schneider-Str. 2 / E1Wuerzburg97080Germany

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Highlights

•	SARS-CoV-2 rapid antigen detection tests (RDT) were evaluated among children.
•	9760 oropharyngeal samples in paediatric patients were enrolled.
•	RDT sensitivity was 44.7% compared to RT-qPCR.
•	SARS-CoV-2 virus variant of concern and COVID-19 vaccination status did not have a significant impact of RDT sensitivity.

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Keywords : SARS-CoV-2 antigen rapid diagnostic test, PCR, Clinical performance evaluation, Paediatric, Children, COVID-19 vaccination, SARS-CoV-2 virus variants of concern

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Vol 86 - N° 3

P. 256-308 - mars 2023 Retour au numéro

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Clinical accuracy of SARS-CoV-2 rapid antigen testing in screening children and adolescents - 28/02/23

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