Safety and Tolerability of COVID-19 Vaccine in Children With Epilepsy: A Prospective, Multicenter Study - 02/03/23
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Abstract |
Background |
We designed this study to investigate the effects of the coronavirus disease 2019 (COVID-19) vaccine on epileptic seizures, as well as its adverse effects, in children with epilepsy (<18 years).
Methods |
This anonymous questionnaire study involved a multicenter prospective survey of outpatients and inpatients with epilepsy (＜18 years) registered in epilepsy clinics in eight hospitals in six cities of Shandong Province.
Results |
A total of 224 children with epilepsy were included in the study. Fifty of them experienced general adverse events after vaccination. The most common local adverse events were pain or tenderness at the injection site. The most common systemic adverse effects were muscle soreness and headache. No severe adverse events were reported. There were no significant differences in the number of antiseizure medications (P = 0.459), gender (P = 0.336), etiology (P = 0.449), age (P = 0.499), duration of disease (P = 0.546), or seizure type (P = 0.475) between the patients with and without general adverse events. We found that the risk of seizure after vaccination was decreased in children who were seizure free for more than six months before vaccination. There was no significant difference in the number of seizures during the first month before vaccination, the first month after the first dose, and the first month after the second dose (P = 0.091).
Conclusion |
The benefits of vaccination against COVID-19 outweighed the risks of seizures/relapses and severe adverse events after vaccination for children with epilepsy.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, Vaccine, Epilepsy, Children
Plan
| Conflict of interest and source of funding statement: The authors declare no conflict of interest or financial disclosures concerning the materials or methods used in this study or the findings specified in this article. |
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| Funding: This work was supported by the National Natural Science Foundation (No. 81873786). The funder did not participate in the work. |
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| Author contributions: Zhihao Wang and Xiqin Fang conceptualized and designed the study, collected and organized the data, drafted the initial manuscript, and reviewed and revised the manuscript. Tao Han, Chunxiang Li, Aihua Ma, Zhaolun Jiang, Shishen Lv, Wenke Li, Wenxiu Sun, Wenying Sun, Yuxing Gao, Zaifen Gao, Yong Liu, Qiubo Li, Suli Wang, Baomin Li, and Xinjie Liu assisted in collecting data and provided important suggestions for the design of research scheme and the writing of manuscript. Xuewu Liu conceptualized and designed the study, coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. |
Vol 140
P. 3-8 - mars 2023 Retour au numéro
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