Reproducible Microstructural Changes in the Brain Associated With the Presence and Severity of Urologic Chronic Pelvic Pain Syndrome (UCPPS): A 3-Year Longitudinal Diffusion Tensor Imaging Study From the MAPP Network - 04/04/23
Highlights |
• | This study evaluated differences in brain diffusion MRI between UCPPS and healthy controls. |
• | Diffusion was altered in areas associated with pain perception, integration, and modulation. |
• | Improvement of diffusion characteristics were correlated with reduced pain severity. |
Abstract |
Microstructural alterations have been reported in patients with urologic chronic pelvic pain syndrome (UCPPS). However, it isn't clear whether these alterations are reproducible within 6 months or whether long-term symptom improvement is associated with specific microstructural changes. Using data from the MAPP-II Research Network, the current study performed population-based voxel-wise DTI and probabilistic tractography in a large sample of participants from the multicenter cohort with UCPPS (N = 364) and healthy controls (HCs, N = 61) over 36 months. While fractional anisotropy (FA) differences between UCPPS patients and HCs were observed to be unique at baseline and 6-month follow-up visits, consistent aberrations in mean diffusivity (MD) were observed between UCPPS and HCs at baseline and repeated at 6 months. Additionally, compared to HCs, UCPPS patients showed stronger structural connectivity (SC) between the left postcentral gyrus and the left precuneus, and weaker SC from the left cuneus to the left lateral occipital cortex and the isthmus of the left cingulate cortex at baseline and 6-month. By 36 months, reduced FA and MD aberrations in these same regions were associated with symptom improvement in UCPPS. Together, results suggest changes in white matter microstructure may play a role in the persistent pain symptoms in UCPPS.
Perspective |
This longitudinal study identified reproducible, “disease-associated” patterns in altered mean diffusivity and abnormal microstructural connectivity in UCPPS comparing to HCs over 6 months. These differences were found in regions involved in sensory processing and integration and pain modulation, making it potentially amenable for clinical interventions that target synaptic and/or neuronal reorganization.
Le texte complet de cet article est disponible en PDF.Key words : Urological chronic pelvic pain, UCPPS, Longitudinal observation, Diffusion tensor imaging, Probabilistic tractography
Plan
| This study was funded by grants from the NIH/NINDS R01 NS078494 (Ellingson) and NIH/NIDDK U54 DK064539 (Ellingson, Mayer, Labus). |
|
| BME is a consultant for Medicenna, MedQIA, Agios/Servier, Siemens, Janssen Pharmaceuticals, Imaging Endpoints, Kazia, Oncoceutics/Chimerix, Sumitomo Dainippon Pharma Oncology, ImmunoGenesis, Ellipses Pharma, Monteris, Neosoma, the Global Coalition for Adaptive Research (GCAR), and the NIH. BME receives research grant funding from Siemens, Janssen, and Neosoma. |
Vol 24 - N° 4
P. 627-642 - avril 2023 Retour au numéro
Article précédent
- Neonatal Outcomes Associated With in Utero Exposure to Oxycodone, Overall and by Trimester of Exposure: A Retrospective Cohort Study
- Erin Kelty, Mishka Terplan, Carol Orr, David B. Preen
- Depressive and Insomnia Symptoms Sequentially Mediate the Association Between Racism-Based Discrimination in Healthcare Settings and Clinical Pain Among Adults With Sickle Cell Disease
- Lakeya S. McGill, Katrina R. Hamilton, Janelle E. Letzen, Patrick H. Finan, Sophie M. Lanzkron, Michael T. Smith, Jennifer A. Haythornthwaite, Claudia M. Campbell
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?