A U-shaped association between dietary phosphorus intake and new-onset hypertension: a nationwide cohort study in China - 06/04/23

Doi : 10.1016/j.ahj.2023.01.013

Qimeng Wu, MD ^a, Ziliang Ye, MD ^a, Chun Zhou, MD ^a, Mengyi Liu, MD ^a, Yuanyuan Zhang, MD ^a, Zhuxian Zhang, MD ^a, Panpan He, MD ^a, Rui Li, MS ^b,^c, Huan Li, MD ^a, Sisi Yang, MD ^a, Yanjun Zhang, MD ^a, Jianping Jiang, MD ^a, Jing Nie, MD ^a, Chengzhang Liu, MS ^a,^b,^c,^{^{1
Xianhui Qin and Chengzhang Liu contributed equally to this article.}}, Xianhui Qin, MD ^a,^b,^c,^⁎,^{^{1
Xianhui Qin and Chengzhang Liu contributed equally to this article.}}
^a Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China
^b Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China
^c Institute of Biomedicine, Anhui Medical University, Hefei, 230032, China

^⁎Corresponding author: Xianhui Qin, MD, National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.National Clinical Research Center for Kidney DiseaseState Key Laboratory for Organ Failure ResearchDivision of NephrologyNanfang HospitalSouthern Medical UniversityGuangzhou510515China

Résumé

Background

The association between dietary phosphorus intake and the risk of hypertension remains uncertain. We aimed to investigate the relation of dietary phosphorus intake with new-onset hypertension among Chinese adults.

Methods

A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey (CHNS) were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. New-onset hypertension was defined as systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg or diagnosed by a physician or under antihypertensive treatment during the follow-up.

Results

During a median follow-up of 6.1 years, 4,269 participants developed new-onset hypertension. Overall, the association between dietary phosphorus intake and new-onset hypertension followed a U-shape (P for nonlinearity<.001). Consistently, when dietary phosphorus intake was assessed as quintiles, compared with those in the 3rd to 4th quintiles (912.0-<1089.5 mg/d), a significantly higher risk of new-onset hypertension was found in participants in the 1st to 2nd quintiles (<912.0 mg/d: HR, 1.23; 95% CI, 1.14-1.33), and the fifth quintile (≥1089.5 mg/d: HR, 1.21; 95% CI, 1.10-1.33).

Conclusion

There was a U-shaped association between dietary phosphorus intake and new-onset hypertension in general Chinese adults.

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List of Abbreviation : CHNS, SBP, DBP, BMI, Na/K, NO

Plan

Methods

Population and study design

Assessment of dietary intake

Assessments of blood pressure and covariates

Study participants and baseline characteristics

Association between dietary phosphorus intake and new-onset hypertension

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Vol 259

P. 21-29 - mai 2023 Retour au numéro

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A U-shaped association between dietary phosphorus intake and new-onset hypertension: a nationwide cohort study in China - 06/04/23

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Background

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Conclusion

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