Permanent section margin concordance after Mohs micrographic surgery with immunohistochemistry for invasive melanoma and melanoma in situ: A retrospective dual-center analysis - 14/04/23
Abstract |
Background |
Mohs micrographic surgery (MMS) for melanoma practices vary among dermatologic surgeons. The implementation of immunohistochemical staining in MMS for melanoma mitigates challenges associated with slide interpretation; however, the reliability of melanoma antigen recognized by T cells 1 (MART-1), the preferred immunostain for melanoma, has yet to be compared with permanent section pathology.
Objective |
To assess concordance rates of MART-1 frozen sections and permanent section pathologic interpretation of melanoma treated with MMS.
Methods |
A dual-center retrospective analysis was conducted to collect concordance and demographic data. Chi-square tests were performed for group comparisons of categorical variables.
Results |
Of the 379 permanent sections sent, 367 were concordant with frozen section pathology for an overall concordance rate of 96.8%. Cases were stratified into indeterminately concordant and indisputably concordant. Twenty-two (6%) of cases were indeterminately concordant, whereas 345 (94.0%) of cases were indisputably concordant.
Limitations |
The concordance rate is derived from a comparison of adjacent tissue margins, an inevitable consequence of utilizing 2 techniques.
Conclusion |
To the author’s knowledge, this study represents the largest investigation examining concordance rates of MART-1 frozen sections in Mohs for melanoma. High concordance disputes the ongoing need for additional permanent margins when using MART-1 in routine cases.
Le texte complet de cet article est disponible en PDF.Key words : concordance, IHC, immunohistochemistry, MART-1, melanoma, Mohs surgery, permanent section
Plan
| Funding sources: None. |
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| IRB approval status: Reviewed and approved by Oregon Health & Science University (OHSU) IRB, approval #17236 and Cedars-Sinai Medical Center (CSMC) IRB #00001546. |
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| Reprints not available from the authors. |
Vol 88 - N° 5
P. 1060-1065 - mai 2023 Retour au numéro
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