An update on Epstein-Barr virus–and human T-lymphotropic virus type-1–induced cutaneous manifestations. CME Part II - 14/04/23

Doi : 10.1016/j.jaad.2022.07.063

Alejandro A. Gru, MD ^a,^b,^⁎ , Jose A. Plaza, MD ^c,^d, Jose A. Sanches, MD ^e, Denis Miyashiro, MD ^e, Omar P. Sangueza, MD ^f,^g, Francisco Bravo Puccio, MD ^h, Sonia Toussaint, MD ⁱ, J. Martin Sangueza, MD ^j
^a Department of Pathology, University of Virginia, Charlottesville, Virginia
^b Department of Dermatology, University of Virginia, Charlottesville, Virginia
^c Department of Pathology, The Ohio State University, Columbus, Ohio
^d Department of Dermatology, The Ohio State University, Columbus, Ohio
^e Department of Dermatology, University of São Paulo, São Paulo, Brazil
^f Department of Pathology, Wake Forest University, Winston-Salem, North Carolina
^g Department of Dermatology, Wake Forest University, Winston-Salem, North Carolina
^h Department of Dermatology, Universidade Peruana Cayetano Heredia, Lima, Peru
ⁱ Department of Dermatology, Hospital General Dr. Manuel Gea González, Mexico DF, Mexico
^j Department of Pathology, Hospital Obrero, La Paz, Bolivia

^∗Correspondence to: Alejandro A. Gru, MD, Departments of Pathology & Dermatology, University of Virginia, 415 Lane Rd, Hospital Expansion Bldg Room 3024, Charlottesville, VA 22908.Departments of Pathology & DermatologyUniversity of Virginia415 Lane Rd, Hospital Expansion Bldg Room 3024CharlottesvilleVA22908

Abstract

The Epstein-Barr virus (EBV) is a DNA virus that infects 90% of the human population, is responsible for certain cutaneous lymphomas (extranodal NK/T-cell lymhoma, hydroa vacciniforme lymphoproliferative disorder, lymphomatoid granulomatosis, others), and can be associated with a variety of cutaneous manifestations (eg, infectious mononucleosis, severe mosquito bite allergy, chronic active EBV disease, Gianotti-Crosti syndrome). EBV-related skin disorders are frequent in certain populations (South and Cental America, Africa, Asia, and Oceania) and can be diagnostically challenging. The human T-lymphotropic virus type-1 is a retrovirus, which is known to be associated with adult T-cell leukemia/lymphoma, neurologic disorders, but also cutaneous non-neoplastic manifestations (infective dermatitis, infections, and infestations). We performed an updated revision of the clinical dermatologic and histopathologic findings associated with the cutaneous non-neoplastic and preneoplastic disorders occurring in association with the EBV and human T-lymphotropic virus type-1.

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Key words : chronic active EBV disease, Gianotti-Crosti syndrome, infectious mononucleosis, infective dermatitis, infestations, Lipschutz ulcer, severe mosquito bite allergy

Abbreviations used : ATLL, CAEBV, EBV, GCS, HTLV-1, ID, IM, LU, SMBA

Plan

Introduction

Infectious mononucleosis

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Severe mosquito bite allergy

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Chronic active EBV disease

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Lipschutz ulcers

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Gianotti-Crosti syndrome

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HTLV-1--associated ID

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Infections and infestations associated with HTLV-1 infection

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Conclusions

	Funding sources: None.
	IRB approval status: Not applicable.
	Patient consent: Consent for the publication of recognizable patient photographs or other identifiable material was obtained by the authors and included at the time of article submission to the journal stating that all patients gave consent with the understanding that this information may be publicly available.
	Date of release: May 2023.
	Expiration date: May 2026.
	Reprints not available from the authors.