Pathogenèse et évolution de la sclérose latérale amyotrophique - 27/04/23
Pathogenesis and evolution of Amyotrophic Lateral Sclerosis
, Clémentine Tourlet bRésumé |
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder resulting from damage to motor neurons. Mostly sporadic, ALS is qualified as « familial » in 5 % of cases. Its origin lies in predisposing genetic factors and environmental factors. There are two main forms, spinal and bulbar, depending on the initial topography of the deficits. In any case, there is a decrease in muscular strength that becomes more and more extensive. This usually leads to acute respiratory failure and death after a few years of evolution. ALS is a condition that can be difficult to diagnose. Affected patients require regular and multidisciplinary care to best support them from diagnosis to the end of life.
Le texte complet de cet article est disponible en PDF.Summary |
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder resulting from damage to motor neurons. Mostly sporadic, ALS is qualified as « familial » in 5% of cases. Its origin lies in predisposing genetic factors and environmental factors. There are two main forms, spinal and bulbar, depending on the initial topography of the deficits. In any case, there is a decrease in muscular strength that becomes more and more extensive. This usually leads to acute respiratory failure and death after a few years of evolution. ALS is a condition that can be difficult to diagnose. Affected patients require regular and multidisciplinary care to best support them from diagnosis to the end of life.
Le texte complet de cet article est disponible en PDF.Mots clés : Maladie de Charcot, Maladie neurodégénérative, Maladie neuromusculaire, Physiopathologie, Sémiologie, SLA
Keywords : Motor neuron disease, Neurodegenerative disease, Neuromuscular disease, Physiopathology, Semiology, ALS
Plan
Vol 23 - N° 257
P. 4-10 - mai 2023 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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