Rapid multiplex PCR for respiratory viruses reduces time to result and improves clinical care: Results of a systematic review and meta-analysis - 27/04/23
, Kristina Lindsley d , Tara B. Wigmosta e , Anil Bhagat f , Rachael B. Hemmert e , Jennifer Uyei g , Tristan T. Timbrook e, h Summary |
Objectives |
The clinical impact of rapid sample-to-answer “syndromic” multiplex polymerase chain reaction (PCR) testing for respiratory viruses is not clearly established. We performed a systematic literature review and meta-analysis to evaluate this impact for patients with possible acute respiratory tract infection in the hospital setting.
Methods |
We searched EMBASE, MEDLINE, and Cochrane databases from 2012 to present and conference proceedings from 2021 for studies comparing clinical impact outcomes between multiplex PCR testing and standard testing.
Results |
Twenty-seven studies with 17,321 patient encounters were included in this review. Rapid multiplex PCR testing was associated with a reduction of − 24.22 h (95% CI −28.70 to −19.74 h) in the time to results. Hospital length of stay was decreased by −0.82 days (95% CI −1.52 to −0.11 days). Among influenza positive patients, antivirals were more likely to be given (RR 1.25, 95% CI 1.06–1.48) and appropriate infection control facility use was more common with rapid multiplex PCR testing (RR 1.55, 95% CI 1.16–2.07).
Conclusions |
Our systematic review and meta-analysis demonstrates a reduction in time to results and length of stay for patients overall along with improvements in appropriate antiviral and infection control management among influenza-positive patients. This evidence supports the routine use of rapid sample-to-answer multiplex PCR testing for respiratory viruses in the hospital setting.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The clinical impact of rapid multiplex testing for respiratory viruses is not known. |
• | This meta-analysis of 27 studies evaluates the impact compared with standard testing. |
• | Rapid multiplex testing was associated with reduced time to results and length of stay. |
• | Rapid multiplex testing improved antiviral use and infection control in influenza patients. |
• | These results support rapid multiplex PCR tests in suspected respiratory infections. |
Keywords : Rapid test, Multiplex PCR, Respiratory virus, Clinical impact, Syndromic panel, COVID-19, Influenza
Plan
Vol 86 - N° 5
P. 462-475 - mai 2023 Retour au numéro
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