Mechanistic correlation between mitochondrial permeability transition pores and mitochondrial ATP dependent potassium channels in ischemia reperfusion - 29/04/23

Doi : 10.1016/j.biopha.2023.114599

Rajalaxmi Behera ^a,^{^{1
Both authors contributed equally to the work}}, Veerta Sharma ^a, Amarjot Kaur Grewal ^a, Amit Kumar ^a, Bhaskar Arora ^a, Agnieszka Najda ^b,^⁎ , Ghadeer M. Albadrani ^c, Ahmed E. Altyar ^d,^e, Mohamed M. Abdel-Daim ^f,^g, Thakur Gurjeet Singh ^a,^⁎,^{^{1
Both authors contributed equally to the work},}^{^{2
Orcid Id: 0000-0003-2979-1590},}^{^{3
Scopus Author Id: 27667828700}}

^a Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India

^b Department of Vegetable and Herbal Crops, University of Life Sciences in Lublin, 50 A Doświadczalna Street, 20-280 Lublin, Poland

^c Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia

^d Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, P.O. Box 80260, Jeddah 21589, Saudi Arabia

^e Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia

^f Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia

^g Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

^⁎ Correspondence to: Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin, 15 Akademicka Street, 20-950 Lublin, Poland. Department of Vegetable Crops and Medicinal Plants, University of Life Sciences in Lublin 15 Akademicka Street Lublin 20-950 Poland ^⁎⁎ Corresponding author.

Abstract

Mitochondrial dysfunction is one of the fundamental causes of ischemia reperfusion (I/R) damage. I/R refers to the paradoxical progression of cellular dysfunction and death that occurs when blood flow is restored to previously ischemic tissues. I/R causes a significant rise in mitochondrial permeability resulting in the opening of mitochondrial permeability transition pores (MPTP). The MPTP are broad, nonspecific channels present in the inner mitochondrial membrane (IMM), and are known to mediate the deadly permeability alterations that trigger mitochondrial driven cell death. Protection from reperfusion injury occurs when long-term ischemia is accompanied by short-term ischemic episodes or inhibition of MPTP from opening via mitochondrial ATP dependent potassium (mitoK _ATP ) channels. These channels located in the IMM, play an essential role in ischemia preconditioning (PC) and protect against cell death by blocking MPTP opening. This review primarily focuses on the interaction between the MPTP and mitoK _ATP along with their role in the I/R injury. This article also describes the molecular composition of the MPTP and mitoK _ATP in order to promote future knowledge and treatment of diverse I/R injuries in various organs.

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Abbreviations : I/R, ROS, IMM, MPTP, mitoK _ATP , VDAC, PBR, OSCP, PI3-K, GPCRs, PIP3, PDK, ERK, eNOS, PKG, JAK/STAT, RISK

Keywords : Mitochondrial permeability transition pores, Mitochondrial ATP dependent potassium channels, Ischemia reperfusion, Reactive oxygen species, Protein kinase C