Dietary Patterns and Practices and Leucocyte Telomere Length: Findings from the UK Biobank - 18/05/23
, Christopher P. Nelson, PhD 1, 2, Qingning Wang, PhD 1, 2, Crispin Musicha, PhD 4, Veryan Codd, PhD 1, 2, Nilesh J. Samani, MD 1, 2Abstract |
Background |
Shorter telomere length (TL) is associated with risk of several age-related diseases and decreased life span, but the extent to which dietary patterns and practices associate with TL is uncertain.
Objective |
This study aimed to investigate the association of dietary patterns and practices and leucocyte TL (LTL).
Design |
This was a cross-sectional study.
Participants and setting |
Data collected voluntarily from up to 422,797 UK Biobank participants, during 2006-2010.
Main outcome measures |
LTL was measured as a ratio of the telomere repeat number to a single-copy gene and was loge-transformed and standardized (z-LTL).
Statistical analyses performed |
Adherence a priori to a Mediterranean-style diet was assessed through the MedDietScore. Principal component analysis was used to a posteriori extract the “Meat” and “Prudent” dietary patterns. Additional dietary practices considered were the self-reported adherence to “Vegetarian” diet, “Eating 5-a-day of fruit and vegetables” and “Abstaining from eggs/dairy/wheat/sugar.” Associations between quintiles of dietary patterns or adherence to dietary practices with z-LTL were investigated through multivariable linear regression models (adjusted for demographic, lifestyle, and clinical characteristics).
Results |
Adherence to the “Mediterranean” and the “Prudent” patterns, was positively associated with LTL, with an effect magnitude in z-LTL of 0.020 SD and 0.014 SD, respectively, for the highest vs the lowest quintile of adherence to the pattern (both P values < 0.05). Conversely, a reversed association between quintile of the “Meat” pattern and LTL was observed, with z-LTL being on average shorter by 0.025 SD (P = 6.12×10–05) for participants in the highest quintile of the pattern compared with the lowest quintile. For adherents to “5-a-day” z-LTL was on average longer by 0.027 SD (P = 5.36×10–09), and for “abstainers,” LTL was shorter by 0.016 SD (P = 2.51×10–04). The association of LTL with a vegetarian diet was nonsignificant after adjustment for demographic, lifestyle, and clinical characteristics.
Conclusions |
Several dietary patterns and practices associated with beneficial health effects are significantly associated with longer LTL. However, the magnitude of the association was small, and any clinical relevance is uncertain.
Le texte complet de cet article est disponible en PDF.Keywords : Telomere length, Dietary patterns, Mediterranean diet, Longevity
Plan
| Supplementary materials Table 3, and Table 5, Table 6, Table 7, Table 8, Table 9, Table 10, Table 11, Table 12, Table 13, Table 14, and Figure 1, Figure 4, and Figure 5 are available at www.jandonline.org |
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| STATEMENT OF POTENTIAL CONFLICT OF INTEREST No potential conflict of interest was reported by the authors. |
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| FUNDING/SUPPORT This work was funded by the UK Medical Research Council (MRC), Biotechnology, and Biological Sciences Research Council and British Heart Foundation (BHF) through MRC grant MR/M012816/1. University of Leicester investigators are supported by the National Institute for Health Research Leicester Cardiovascular Biomedical Research Centre (BRC-1215-20010). C. Nelson is funded by the BHF (SP/16/4/32697). |
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| ACKNOWLEDGEMENT UK Biobank received approval from the North West Centre for Research Ethics Committee (11/NW/0382). The use of data presented in this article was approved by the Access Committee of the UK Biobank under application No 6077. |
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| AUTHOR CONTRIBUTIONS V. Bountziouka and NJS conceptualized and designed this study; V. Bountziouka, Q. Wang, and C. Musicha performed the data management; V. Bountziouka analyzed and interpreted the data with advice from C. Nelson; V. Codd, C. Nelson, and N. Samani were responsible for data acquisition; N. Samani acquired the financial support for the project leading to this publication; V. Bountziouka and N. Samani drafted the manuscript. All authors commented on subsequent drafts of the manuscript and critically reviewed it for important intellectual content and gave their final approval to the version to be published. |
Vol 123 - N° 6
P. 912 - juin 2023 Retour au numéro
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