Clinical Course Associated with Aseptic Meningitis Induced by Intravenous Immunoglobulin for the Treatment of Multisystem Inflammatory Syndrome in Children - 17/06/23
Doi : 10.1016/j.jpeds.2023.01.025
Cameron C. Young, BS 1, Kerri L. LaRovere, MD 2, Margaret M. Newhams, MPH 1, Suden Kucukak, MD 1, Shira J. Gertz, MD 3, Aline B. Maddux, MD 4, Natasha B. Halasa, MD 5, Hillary Crandall, MD, PhD 6, Michele Kong, MD 7, Julie C. Fitzgerald, MD, PhD 8, Katherine Irby, MD 9, Adrienne G. Randolph, MD 1, 10, Angela P. Campbell, MD, MPH 11, †, Mary Beth F. Son, MD 12, ⁎, † 
on behalf of the
on behalf of the
Overcoming COVID-19 Investigators∗
1 Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA
2 Department of Neurology, Boston Children's Hospital, Boston, MA
3 Division of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center, Livingston, NJ
4 Department of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO
5 Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN
6 Division of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT
7 Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
8 Division of Critical Care, Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
9 Section of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, AR
10 Departments of Anaesthesia and Pediatrics, Harvard Medical School, Boston, MA
11 COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA
12 Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA
∗Reprint requests: Mary Beth F. Son, MD, Boston Children's Hospital, 300 Longwood Ave., Fegan, 6th Floor, Boston, MA 02115Boston Children's Hospital300 Longwood Ave.Fegan, 6th FloorBostonMA02115
Abstract |
Aseptic meningitis is a rare but potentially serious complication of intravenous immunoglobulin treatment. In this case series, meningitic symptoms following intravenous immunoglobulin initiation in patients with multisystem inflammatory syndrome were rare (7/2,086 [0.3%]). However, they required the need for additional therapy and/or readmission.
Le texte complet de cet article est disponible en PDF.Keywords : drug-induced aseptic meningitis, SARS-CoV-2, multisystem inflammatory syndrome in children (MIS-C), intravenous immunoglobulin
Abbreviations : ICU, IVIG, KD, LP, MIS-C, RT-PCR, SARS-CoV-2
Plan
| J.C.F. reported receiving funding from the NIH ( K23DK119463 ) outside of the submitted work. |
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| Funding: This work was supported by the US Centers for Disease Control and Prevention . The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the U.S. Centers for Disease Control and Prevention. |
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| Role of the Funder/Sponsor: The funder participated in the design and conduct of the surveillance investigation; collection, management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; and decision to submit the manuscript for publication. |
© 2023
Elsevier Inc. Tous droits réservés.
Vol 257
Article 113372- juin 2023 Retour au numéro
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