Defects of the scalp and calvarium pose unique reconstructive challenges due to the importance of this area in protecting the brain and its distance from larger donor vessels for free flap transfer. The wide range and complexity of reconstructive options make this a broad topic because the simplest defects are often closed or managed in the outpatient setting and the most complex require multilayer closure in the operating room with a multidisciplinary team and intensive postoperative care. In hair-bearing individuals, the scalp is an esthetically important area due to the importance of hair to self-esteem and sexual attraction.