Self-propelling thrombin powder enables hemostasis with no observable recurrent bleeding or thrombosis over 3 days in a porcine model of upper GI bleeding - 14/07/23
Abstract |
Background and Aims |
Hemostatic powders used to manage upper GI bleeding continue to exhibit high recurrent bleeding rates. Previously, self-propelling thrombin powder (SPTP) sprayed endoscopically managed severe Forrest class 1A bleeding. Here, we evaluate SPTP in a 3-day recovery model of diffuse ulcerated bleeding.
Methods |
Five anesthetized pigs underwent an endoscopic mucosal snare resection to trigger diffuse ulcer bleeding and were treated with SPTP. The time to hemostasis and the amount of powder delivered were measured. Pigs were recovered and monitored.
Results |
Five pigs achieved hemostasis in 4.5 ± 1.2 minutes At 3 days after the procedure, the pigs were rescoped and showed no recurrent bleeding. Measured blood parameters were not significantly different from baseline. There were no signs of foreign bodies or thromboembolism during gross necropsy and histopathology of key organs.
Conclusions |
SPTP is a promising novel material that stopped diffuse ulcer bleeding in 5 pigs without recurrent bleeding or adverse local or systemic events.
Le texte complet de cet article est disponible en PDF.Abbreviations : SPTP, TXA
Plan
| DISCLOSURE: The following authors disclosed financial relationships: N. Ali-Mohamad: Employee of CoMotion Drug Delivery Systems Inc. M. F. Cau: Shareholder in CoMotion Drug Delivery Systems Inc. J. R. Baylis: Director of and shareholder in CoMotion Drug Delivery Systems Inc. F. Donnellan: Advisor for CoMotion Drug Delivery Systems Inc. C. J. Kastrup: Director of and shareholder in CoMotion Drug Delivery Systems Inc, NanoVation Therapeutics, and SeraGene Therapeutics. All other authors disclosed no financial relationships. Research support for this study was provided by an American Society of Gastrointestinal Endoscopy Research Award, the Canadian Institutes of Health Research (PJT-175044), the U.S. Department of Defense (W81XWH-21-1-0969), and the Center for Blood Research. |
Vol 98 - N° 2
P. 245-248 - août 2023 Retour au numéro
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