Can serum tumor necrosis factor-alpha predict peritoneal adhesions prior to secondary laparoscopic procedures? - 02/08/23
, S. Basim b, Y. Ozdenkaya cHighlights |
• | Previous abdominal surgeries inevitably cause intra-abdominal adhesions. |
• | Intra-abdominal adhesions are a condition that negatively affects recovery after major abdominal surgery and can cause complications in the patient. |
• | Knowing the severity and extent of intra-abdominal adhesions in the preoperative period in patients with a history of previous abdominal surgery helps to predict the complications that may be encountered. |
• | Preoperative TNF-α values are an essential marker in predicting the presence and extent of POA. |
Summary |
Aim of the study |
This study aimed to investigate the incidence and degree of postoperative intra-abdominal adhesions(POAs) in secondary laparoscopic procedures and assess the power of the preoperative levels of tumor necrosis factor-alpha(TNF-α) and interleukin-1 beta(IL-1β) and selected peripheral inflammatory biomarkers(PIBs) in the prediction of the development and extent of POA.
Patients and methods |
This prospective study enrolled 103 patients who had previously undergone at least one or more laparoscopic abdominal or gynecological operations. We examined TNF-α, IL-1β, and PIBs, namely C-reactive protein, white blood cell count, neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio, and systemic immune-inflammation index(SII) according to the presence, location, and score of adhesions determined during secondary laparoscopic procedures.
Results |
Only age, postoperative adhesion index(PAI) score, NLR, SII, TNF-α, and IL-1β resulted in a significant difference in the existence of adhesion(P<0.05). The correlation analysis of TNF-α with variables showed that the PAI score and IL 1β levels had a significantly positive correlation.
Conclusion |
The presence and extent of POA could be predicted by examining the preoperative TNF-α level in patients who had laparoscopic abdominal surgery previously. We could overcome adverse events during secondary laparoscopic procedures by assessing high-risk patients and integrating a personalized surgical approach to managing selected patients.
Le texte complet de cet article est disponible en PDF.Keywords : Tumor necrosis factor alpha, Intraabdominal adhesions, Laparoscopic surgery
Plan
Vol 160 - N° 4
P. 261-268 - août 2023 Retour au numéro
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