Lung Function Decline in Young Adulthood and Coronary Artery Calcium Progression in Midlife - 22/08/23
, Pin-Ming Liu, MD, PhD a, ⁎ Abstract |
Background |
Reduced lung function has been linked to cardiovascular disease, but population-based evidence on the relationship between lung function decline and coronary artery calcium (CAC) progression is rare.
Methods |
A total of 2694 participants (44.7% men) with a mean ± standard deviation age of 40.4 ± 3.6 years from the Coronary Artery Risk Development in Young Adults (CARDIA) were included. The rates of decline in forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) over a 20-year period were calculated for each participant and categorized into quartiles. The primary outcome was CAC progression.
Results |
During a mean follow-up of 8.9 years, 455 (16.9%) participants had CAC progression. After adjusting for traditional cardiovascular risk factors, the hazard ratios (95% confidence intervals [CIs]) for CAC progression were higher for participants in the 2nd (Q2), 3rd (Q3), and highest quartiles (Q4) of FVC decline compared with those in the lowest quartile (Q1): 1.366 (1.003-1.861), 1.412 (1.035-1.927), and 1.789 (1.318-2.428), respectively. Similar trends were observed for the association between FEV1 and CAC progression. The association remained robust across a series of sensitivity analyses and all subgroups.
Conclusions |
A faster decline in FVC or FEV1 during young adulthood is independently associated with an increased risk of CAC progression in midlife. Maintaining optimal lung function during young adulthood may improve future cardiovascular health.
Le texte complet de cet article est disponible en PDF.Keywords : Cardiovascular disease, Coronary artery calcium, Forced vital capacity, Lung function, Risk factors
Plan
| Clinical trial registration number: The CARDIA study was registered at clinicaltrials.gov as NCT00005130. |
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| Funding: This work was supported by grants from National Natural Science Foundation of China (82170457, 81900379, 81870315, 81970683) and Natural Science Foundation of Guangdong Province, China (2022A1515011920). The CARDIA study (Coronary Artery Risk Development in Young Adults) was also supported by contracts HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201- 800006I, and HHSN268201800007I from the National Heart, Lung, and Blood Institute. The supporting organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. |
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| Conflicts of Interest: None. |
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| Authorship: All authors had access to the data and a role in writing this manuscript. |
Vol 136 - N° 9
P. 910 - septembre 2023 Retour au numéro
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