Electroclinical Features and Long-Term Photosensitivity Outcome in Patients With Photoparoxysmal Response With Epilepsy - 01/09/23
Abstract |
Background |
To investigate electroclinical phenotypes and long-term photosensitivity outcome in a large pediatric cohort of patients with epilepsy with photosensitivity.
Methods |
Patients with epilepsy with photosensitivity with four or more years of follow-up were included. Sustained terminal remission (STR) of photosensitivity (≥3.5 years) and seizure control were investigated, as well as the prognostic factors of photosensitivity. Furthermore, a cluster analysis was used to study the different subgroups of photoparoxysmal responses (PPR).
Results |
We included 190 individuals with a median age at diagnosis of photosensitivity of 93.1 months (interquartile range [IQR] 62.8 to 120 months) and a median follow-up duration of 68.5 months (IQR 51.8 to 84 months). STR of photosensitivity was achieved in 97 (51.1%) patients, and the mean time from age at diagnosis of photosensitivity onset to STR was 16.5 months. Age at the last follow-up (9 to 18 years [P = 0.001]), a history of photoconvulsive response (PCR) (P = 0.009), and posterior epileptiform discharges (EDs) of PPRs (P = 0.05) were significantly associated with a lower chance of entering STR according to a Cox proportional hazards model. The subgroup of generalized epilepsy syndrome exhibited 46.2% of eye closure sensitivity and 47.7% of PCR. The rates of focal epilepsy syndrome (cluster 1), generalized epilepsy syndrome (cluster 2), and unclassified epilepsy (cluster 3) were similar and not statistically different in photosensitive outcome (P = 0.527).
Conclusions |
Age nine to 18 years, a history of PCR, and posterior EDs of PPRs were the adverse factors affecting photosensitivity, suggesting the effect of age-related brain changes in STR. There was no difference in the prognosis of photosensitivity in different epileptic syndromes.
Le texte complet de cet article est disponible en PDF.Keywords : Epilepsy, Photosensitive, Photoparoxysmal responses, Electroclinical features
Plan
| Funding: This work was supported by National Natural Science Foundation of China (82171436), Capital's Funds for Health Improvement and Research (2020-2-4077), and the Foundation of 2018 Beijing Key Clinical Specialty Construction Project-Pediatrics (No. 2199000726). |
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| Consent for publication: This study was approved by the Ethical Committee of Peking University First Hospital, approval number: 2016-1135. Written informed consent was obtained from the legal guardians (parents) of the patient. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. |
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| Author contributions: Dr. Zhixian Yang conceptualized and designed the study, coordinated the study overall, and revised the manuscript; Dr. Yue Niu codesigned the study, drafted the initial manuscript, and revised the manuscript; Dr. Pan Gong, Xianru Jiao, Zhao Xu, Zongpu Zhou, Yuehua Zhang, and Jiong Qin helped to collect and summarize data and revised the manuscript. All authors approved of the final revision of the article. |
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| Data availability statement: The data that support the findings of this study are available on reasonable request from the corresponding author. |
Vol 147
P. 88-94 - octobre 2023 Retour au numéro
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