Should Antihypertensive Medications Be Routinely Administered in the Nighttime Instead of Daytime? - 20/09/23
, Felix Berglund, MD a, Luke Laffin, MD b, Nicholas Ruthmann, MD, MPH bAbstract |
The optimal timing for administering antihypertensive medications remains a topic of debate. This review examines the effectiveness of nighttime vs daytime administration of antihypertensive medications in controlling blood pressure (BP). The MAPEC and Hygia trials suggest that nighttime dosing achieves better BP control and significantly lowers cardiovascular events. However, concerns about methodology and generalizability have been raised. In contrast, the HARMONY and TIME trials found no significant difference in BP control nor cardiovascular outcomes between daytime and nighttime dosing. Current research suggests that the timing of antihypertensive medication administration may not be a crucial factor. Therefore, the decision about the timing of antihypertensive medications administration should be individualized, taking into account patient preference and clinical context, in order to promote consistent compliance.
Le texte complet de cet article est disponible en PDF.Keywords : Antihypertensives, Daytime, Evening, Hypertension, Nighttime
Plan
| Funding: The authors received no external funding support for this manuscript. |
|
| Conflicts of Interest: LL reports a relationship with Medtronic that includes consulting or advisory; a relationship with Eli Lilly and Company that includes consulting or advisory; a relationship with Mineralys Therapeutics, Inc. that includes consulting or advisory; a relationship with AstraZeneca that includes consulting or advisory and funding grants; a relationship with CRISPR Therapeutics that includes consulting or advisory; a relationship with LucidAct Health that includes equity or stocks; and a relationship with Gordy Health that includes equity or stocks. |
|
| Authorship: We confirm that all of the authors participated in the preparation of the manuscript. We verify that all authors had access to the data and a role in writing the manuscript. |
Vol 136 - N° 10
P. 975-978 - octobre 2023 Retour au numéro
Article précédent
- The Fatty Kidney and Beyond: A Silent Epidemic
- Nang San Hti Lar Seng, Petras Lohana, Shruti Chandra, Belinda Jim
- Leveling Up: A Review of Machine Learning Models in the Cardiac ICU
- Zain Khalpey, Parker Wilson, Yash Suri, Hunter Culbert, Jessa Deckwa, Amina Khalpey, Brynne Rozell
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?