Optimization of dual-energy CT (DECT) workflow is critical for successful integration of DECT into practice. Patient selection strategies differ by scanner type and may be based on patient size, exam indication, or both. All stakeholders involved in patient scheduling and scan acquisition should be involved in patient triage to DECT. Automation of DECT postprocessing frees up technologist and radiologist time, but care must be taken to avoid sending unnecessary reconstructions to PACS. DECT use in the Emergency Department aids in incidentaloma characterization and improves reader diagnostic confidence, and results in quantifiable cost savings by eliminating the need for follow-up exams.