EUS-guided gallbladder drainage using a lumen-apposing metal stent as rescue treatment for malignant distal biliary obstruction: a large multicenter experience - 18/10/23
, Andrea Anderloni, MD, PhD 2, Alessandro Fugazza, MD 3, Arnaldo Amato, MD 4, Germana de Nucci, MD 5, Alessandro Redaelli, MD 6, Roberto Di Mitri, MD 7, Luigi Cugia, MD 8, Valeria Pollino, MD 9, Raffaele Macchiarelli, MD 10, Benedetto Mangiavillano, MD 11, Edoardo Forti, MD 12, Mario Luciano Brancaccio, MD 13, Roberta Badas, MD 14, Marcello Maida, MD 15, Emanuele Sinagra, MD 16, Alessandro Repici, Prof. 3, 17, Carlo Fabbri, MD 1, Ilaria Tarantino, MD, PhD 18Abstract |
Background and Aims |
EUS-guided gallbladder drainage (EUS-GBD) with lumen-apposing metal stents (LAMSs) has been reported as a rescue treatment with encouraging results for the relief of jaundice in patients with distal malignant biliary obstruction (DMBO) and after failure of both ERCP and EUS-guided choledochoduodenostomy.
Methods |
This was a multicenter retrospective analysis of all cases of consecutive EUS-GBD with LAMSs used as a rescue treatment for patients with DMBO in 14 Italian centers from June 2015 to June 2020. Primary endpoints were technical and clinical success, whereas the secondary endpoint was the adverse event (AE) rate.
Results |
Forty-eight patients (52.1% women) with a mean age of 74.3 ± 11.7 years were included in the study. Biliary stricture was related to pancreatic adenocarcinoma (85.4%), duodenal adenocarcinoma (2.1%), cholangiocarcinoma (4.2%), ampullary cancer (2.1%), colon cancer (4.2%), and metastatic breast cancer (2.1%). The mean diameter of the common bile duct was 13.3 ± 2.8 mm. LAMSs were placed transgastrically in 58.3% of cases and transduodenally in 41.7%. Technical success was 100%, whereas clinical success was 81.3%, with a mean total bilirubin reduction after 2 weeks of 66.5%. The mean procedure time was 26.4 minutes, and the mean hospital stay was 9.2 ± 8.2 days. AEs occurred in 5 patients (10.4%): 3 were classified as intraprocedural and 2 were classified as delayed because they occurred after >15 days. When the American Society for Gastrointestinal Endoscopy lexicon was used, 2 AEs were mild and 3 were moderate (2 buried LAMSs). The mean follow-up was 122 days.
Conclusions |
Our study shows that EUS-GBD with LAMSs used as a rescue treatment for patients affected by DMBO represents a valuable option in terms of technical and clinical success rates, with an acceptable AE rate. To the best of our knowledge, this is the largest study concerning the use of this procedure. (Clinical trial registration number: NCT03903523.)
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Abbreviations : AE, ASGE, DMBO, EUS-BD, EUS-CDS, EUS-GBD, GOO, LAMS
Plan
Vol 98 - N° 5
P. 765-773 - novembre 2023 Retour au numéro
Article précédent
- Precise application of topical tranexamic acid to enhance endoscopic hemostasis for peptic ulcer bleeding: a randomized controlled study (with video)
- Hsueh-Chien Chiang, Po-Jun Chen, Er-Hsiang Yang, Ming-Tsung Hsieh, I-Cheng Shih, Hsiu-Chi Cheng, Wei-Lun Chang, Wei-Ying Chen, Hung-Chih Chiu, Hsin-Yu Kuo, Wei-Chu Tsai, Yi-Ning Lo, Kai-Chun Yang, Chien-Ming Chiang, Wei-Chih Chen, Kuan-Kai Huang, Hsu-Huan Tseng, Chiung-Yu Chen, Xi-Zhang Lin, Chiao-Hsiung Chuang
- EUS-guided gallbladder drainage for malignant biliary obstruction: a new paradigm but not so new
- Faisal Kamal
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