Human papillomavirus genotype distribution by cytological status and associated risk factors in the general population of Congolese women living in urban and rural areas: Implications for cervical cancer prevention - 15/11/23
, Luc Magloire Anicet Boumba a, c, Hélène Péré b, d, Parfait Christy Nganga a, David Veyer b, Julien Puech b, Ralph-Sydney Mboumba Bouassa b, e, Privat Malanda-Kiminou a, Donatien Moukassa a, Laurent Bélec b, d, eHighlights |
• | Cervical cancer is the second cancer in women living in the Republic of Congo. |
• | Cervical high risk-HPV infection is highly prevalent in the adult Congolese population. |
• | Cervical high risk-HPV is frequent in young or HIV-infected Congolese women. |
• | The Gardasil-9® HPV vaccine covers less than half of high-risk-HPV circulating in Congo. |
• | HPV vaccination should be combined with HPV molecular screening in Congolese women. |
Abstract |
Introduction |
Cervical cancer related to high risk-human papillomavirus (HR-HPV) is the second female cancer in the Republic of Congo (Congo). We herein evaluated the molecular epidemiology of cervical HPV infection and associated risk factors in Congolese women living in urban (Brazzaville) and rural (Plateaux department) settings.
Patients and methods |
A population-based, cross-sectional survey was conducted to collect demographic and behavioral data among Congolese women, and to obtain endocervical swab samples for HPV DNA molecular detection (Anyplex II HPV28, Seegene, Seoul, South Korea).
Results |
A total of 284 women (mean age: 37.8 years; HIV-1-positivity: 18.6%) were included. The prevalence of HPV DNA cervical shedding was 64.4% [HR-HPV: 80.9%, mainly HPV-16 (15.8%), and HPV-35 and HPV-52 (15.3%); multiple HPV infections: 60.6%; 9-valent HPV Gardasil-9® vaccine genotypes: 42.6%]. 91.6% and 100% of low-grade squamous intraepithelial neoplasia (LSIL) and cervical cancer, respectively, showed HR-HPV. HR-HPV prevalence was higher among students (aOR: 7.9) and HIV-infected women (aOR: 3.1) in Brazzaville, and among women aged between 21–30 years (aOR: 7.2) and HIV-infected women (aOR: 5.1) in the Plateaux department.
Conclusion |
Cervical HR-HPV infection is particularly frequent in young or HIV-infected Congolese women. Prophylactic HPV vaccination combined with primary molecular screening of HR-HPV infection in this country should be extended.
Le texte complet de cet article est disponible en PDF.Keywords : Human papillomavirus, Genotypes, Cervical cytology, Risk factors, Republic of Congo
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Vol 53 - N° 8
Article 104762- octobre 2023 Retour au numéro
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