Does Botulinum Toxin Injection Exacerbate Sarcopenia and Bone Mass in Individuals With Cerebral Palsy? - 17/11/23
Abstract |
Background |
Botulinum toxin (BoNT) causes sarcopenia and low bone mass in animal studies. Whether such effect exists in children and adolescents with spastic cerebral palsy (CP) is not clear yet. To investigate the influences of BoNT on grip strength (GS), skeletal muscle mass, and bone mineral density (BMD) in children and adolescents with spastic CP, we conducted this uncontrolled longitudinal study.
Methods |
The body composition of individuals with spastic CP were measured by dual-energy X-ray absorptiometry at preinjection and at 12 and 24 weeks after BoNT intervention. Sarcopenia was defined as meeting both decreased GS and low muscle mass. Twenty-five participants were enrolled (mean age 8.5 years).
Results |
Before BoNT intervention, four adolescents had sarcopenia and low bone mass. When the body composition was analyzed as four limbs, trunk, and head, the skeletal muscle mass of the injected limbs, appendicular skeletal muscle mass, and total body less head BMD increased significantly over 24-week follow-up period (P = 0.0117, 0.0032, 0.0229), whereas the GS remained unchanged. When the body composition was analyzed as segments derived from bilateral arms, forearms, hands, thighs, and lower legs, the skeletal muscle mass (P = 0.0113) but not BMD of the injected segments increased significantly over the 24 weeks. The prevalence of low muscle mass, decreased GS, sarcopenia, and low bone mass did not change over 24 weeks.
Conclusions |
The present study showed that BoNT does not exacerbate sarcopenia and low bone mass in individuals with spastic CP.
Le texte complet de cet article est disponible en PDF.Keywords : Cerebral palsy, Botulinum toxin, Grip strength, Sarcopenia, Low bone mass
Plan
| Funding: This work was supported by the National Cheng Kung University Hospital (grant numbers NCKUH-11102035, NCKUH-11201005), National Science and Technology Council (NSTC 112-2425-H-006-003, NSTC 112-2314-B-006-039) and in part by Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University. The funders had no role in (1) study design; (2) the collection, analysis, and interpretation of data; (3) the writing of the report; and (4) the decision to submit the manuscript for publication. |
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| Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. |
Vol 149
P. 32-38 - décembre 2023 Retour au numéro
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