Bone and joint infection are commonly associated with disruption of the soft tissue envelope around the skeleton. Respect and consideration must be given to the soft tissue when treating orthopaedic infection as this can be the most challenging part of reconstruction during effective eradication of infection. Failure to plan for soft tissue problems will increase the risk of treatment failure. We describe the role of plastic surgeons and modern approaches to timely and effective joint working to deliver patient-centric care. Reconstructive options for soft tissues are described and the rationale behind our clinical approach.