Stage 2 Registered Report: The Bidirectional Relationship Between Brain Features and the Dysregulation Profile: A Longitudinal, Multimodal Approach - 28/11/23
Abstract |
Objective |
Youth with symptoms of emotion dysregulation are at risk for a multitude of psychiatric diagnoses later in life. However, few studies have focused on the underlying neurobiology of emotion dysregulation. This study assessed the bidirectional relationship between emotion dysregulation symptoms and brain morphology throughout childhood and adolescence.
Method |
A combined total of 8,235 children and adolescents drawn from 2 large population-based cohorts, the Generation R Study and Adolescent Brain Cognitive Development (ABCD) Study, were included. Data were acquired in 3 waves in Generation R (mean [SD] age = 7.8 [1.0] wave 1 [W1]; 10.1 [0.6] W2; 13.9 [0.5] W3) and in 2 waves in ABCD (mean [SD] age = 9.9 [0.6] W1; 11.9 [0.6] W2). Cross-lagged panel models were used to determine the bidirectional relationships between emotion dysregulation symptoms and brain morphology. The study was preregistered before performing analyses.
Results |
In the Generation R sample, emotion dysregulation symptoms at W1 preceded lower hippocampal (β = −.07, SE = 0.03, p = .017) and temporal pole (β = −.19, SE = 0.07, p = .006) volumes at W2. Emotion dysregulation symptoms at W2 preceded lower fractional anisotropy in the uncinate fasciculus (β = −.11, SE = 0.05, p = .017) and corticospinal tract (β = −.12, SE = 0.05, p = .012). In the ABCD sample, emotion dysregulation symptoms preceded posterior cingulate (β = .01, SE = 0.003, p = .014) and nucleus accumbens volumes (left hemisphere: β = −.02, SE = 0.01, p = .014; right hemisphere: β = −.02, SE = 0.01, p = .003).
Conclusion |
In population-based samples, with relatively low psychopathology symptoms in the majority of children, symptoms of emotion dysregulation can precede differential development of brain morphology. This provides the foundation for future work to assess to what extent optimal brain development can be promoted through early intervention.
Study registration information |
The Bidirectional Relationship Between Brain Features and the Dysregulation Profile: A Longitudinal, Multimodal Approach; j.jaac.2022.03.008.
Diversity & Inclusion Statement |
We worked to ensure that the study questionnaires were prepared in an inclusive way. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work.
Le texte complet de cet article est disponible en PDF.Key words : brain morphology, Child Behavior Checklist (CBCL), DTI, emotion dysregulation, structural MRI
Plan
| This article was reviewed under and accepted by Joel Stoddard, MD, MAS. |
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| This work is supported by the Sophia Children’s Hospital Research Foundation (SSWO) Project #S18-68, #S20-48 and the Netherlands Organisation for Health Research and Development (ZonMw) TOP project number 91211021. The general design of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, ZonMw, the Netherlands Organization for Scientific Research (NWO), and the Ministry of Health, Welfare and Sport and is conducted by the Erasmus Medical Center in close collaboration with the Faculty of Social Sciences of the Erasmus University Rotterdam, and the Stichting Trombosedienst en Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. |
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| Part of the data that were used in the preparation of this article will be obtained from the Adolescent Brain Cognitive Development (ABCD) Study (abcdstudy.org), held in the NIMH Data Archive (NDA). This is a multisite, longitudinal study designed to recruit more than 10,000 children age 9-10 and follow them over 10 years into early adulthood. The ABCD Study is supported by the National Institutes of Health (NIH) and additional federal partners under award numbers U01DA041048, U01DA050989, U01DA051016, U01DA041022, U01DA051018, U01DA051037, U01DA050987, U01DA041174, U01DA041106, U01DA041117, U01DA041028, U01DA041134, U01DA050988, U01DA051039, U01DA041156, U01DA041025, U01DA041120, U01DA051038, U01DA041148, U01DA041093, U01DA041089, U24DA041123, and U24DA041147. A full list of supporters is available at federal-partners.html. A listing of participating sites and a complete listing of the study investigators can be found at consortium_members/. ABCD consortium investigators designed and implemented the study and/or provided data but did not and will not necessarily participate in analysis or writing of this report. This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH or ABCD consortium investigators. The ABCD data repository grows and changes over time. The ABCD data used in this report came from 1519007. |
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| The research was performed with permission from the Medical Ethics Committee Erasmus MC. |
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| Consent has been provided for descriptions of specific patient information. |
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| This work has been prospectively registered: fulltext. |
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| Jan van der Ende, PhD, of Erasmus MC, served as the statistical expert for this research. |
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| Author Contributions Conceptualization: Blok, White Formal analysis: Blok Funding acquisition: Blok, White Investigation: Blok Methodology: Blok, Lamballais, White Project administration: White Resources: White Supervision: White Validation: Blok Visualization: Blok, Lamballais, White Writing – original draft: Blok Writing – review and editing: Lamballais, Benítez-Manzanas, White |
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| The authors gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives, and pharmacies in Rotterdam. |
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| Disclosure: Dr. Lamballais, Prof. White, and Mss. Blok and Benítez-Manzanas have reported no biomedical financial interests or potential conflicts of interest. |
Vol 62 - N° 12
P. 1363-1375 - décembre 2023 Retour au numéro
Article précédent
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