Perifollicular linear projections: A dermatoscopic criterion for the diagnosis of lentigo maligna on the face - 13/12/23
, Natalia Jaimes, MD d, e, Stephen W. Dusza, DrPH a, Konstantinos Liopyris, MD a, b, Michael A. Marchetti, MD a, Miguel Cordova, MD a, Margaret Oliviero, ARNP e, Miguel A. Villaseca, MD c, f, Melissa Pulitzer, MD g, Klaus J. Busam, MD g, Anthony M. Rossi, MD a, Harold S. Rabinovitz, MD e, Kishwer S. Nehal, MD a, Alon Scope, MD a, h, Ashfaq A. Marghoob, MD a, ⁎ Abstract |
Background |
Lentigo maligna (LM) can mimic benign, flat, pigmented lesions and can be challenging to diagnose.
Objective |
To describe a new dermatoscopic feature termed “perifollicular linear projections (PLP)” as a diagnostic criterion for LM on the face.
Methods |
Retrospective study on reflectance confocal microscopy and dermatoscopy images of flat facial pigmented lesions originating from 2 databases. PLP were defined as short, linear, pigmented projections emanating from hair follicles. Dermatoscopy readers were blinded to the final histopathologic diagnosis.
Results |
From 83 consecutive LMs, 21/83 (25.3%) displayed “bulging of hair follicles” on reflectance confocal microscopy and 18 of these 21 (85.7%), displayed PLP on dermatoscopy. From a database of 2873 consecutively imaged and biopsied lesions, 252 flat-pigmented facial lesions were included. PLP was seen in 47/76 melanomas (61.8%), compared with 7/176 lesions (3.9%) with other diagnosis (P < .001). The sensitivity was 61.8% (95% CI, 49.9%-72.7%), specificity 96.0% (95% CI, 92.9%-98.4%). PLP was independently associated with LM diagnosis on multivariate analysis (OR 26.1 [95% CI, 9.6%-71.0]).
Limitations |
Retrospective study.
Conclusion |
PLP is a newly described dermatoscopic criterion that may add specificity and sensitivity to the early diagnosis of LM located on the face. We postulate that PLP constitutes an intermediary step in the LM progression model.
Le texte complet de cet article est disponible en PDF.Key words : biopsy, dermatoscopy, face, lentigo maligna, melanoma, reflectance confocal microscopy
Abbreviations used : LM, LPLK, pAK, PLP, RCM, SL
Plan
| Drs Scope and Marghoob are co-senior authors. |
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| Funding sources: This research is funded in part by a grant from the National Cancer Institute / National Institutes of Health (P30-CA008748) made to the Memorial Sloan Kettering Cancer Center. |
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| IRB approval status: This study was approved by the institutional review board of Memorial Sloan Kettering Cancer Center (#99-099). |
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| Patient consent: Consent for the publication of recognizable patient photographs or other identifiable material was obtained by the authors and included at the time of article submission to the journal stating that all patients gave consent with the understanding that this information may be publicly available. |
Vol 90 - N° 1
P. 52-57 - janvier 2024 Retour au numéro
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