Variations in Cortical Functional Gradients Relate to Dimensions of Psychopathology in Preschool Children - 26/12/23
Abstract |
Objective |
It is unclear how the functional brain hierarchy is organized in preschool-aged children, and whether alterations in the brain organization are linked to mental health in this age group. Here, we assessed whether preschool-aged children exhibit a brain organizational structure similar to that of older children, how this structure might change over time, and whether it might reflect mental health.
Method |
This study derived functional gradients using diffusion embedding from resting state functional magnetic resonance imaging data of 4.5-year-old children (N = 100, 42 male participants) and 6.0-year-old children (N = 133, 62 male participants) from the longitudinal Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. We then conducted partial least-squares correlation analyses to identify the association between the impairment ratings of different mental disorders and network gradient values.
Results |
The main organizing axis of functional connectivity (ie, principal gradient) separated the visual and somatomotor regions (ie, unimodal) in preschool-aged children, whereas the second axis delineated the unimodal−transmodal gradient. This pattern of organization was stable from 4.5 to 6 years of age. The second gradient separating the high- and low-order networks exhibited a diverging pattern across mental health severity, differentiating dimensions related to attention-deficit/hyperactivity disorder and phobic disorders.
Conclusion |
This study characterized, for the first time, the functional brain hierarchy in preschool-aged children. A divergence in functional gradient pattern across different disease dimensions was found, highlighting how perturbations in functional brain organization can relate to the severity of different mental health disorders.
Le texte complet de cet article est disponible en PDF.Key words : functional connectivity, cortical gradient, mental disorder, preschool children, resting state functional magnetic resonance imaging
Plan
| This article was reviewed under and accepted by Deputy Editor Melissa Brotman, PhD. |
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| This research is supported by the Singapore National Research Foundation under the Translational and Clinical Research (TCR) Flagship, and Open Fund Large Collaborative Grant (OFLCG) Programmes and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore – NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014; OFLCG/MOH-000504. Additional funding is provided by the Yong Loo Lin School of Medicine, National University of Singapore and the Brain – Body Initiative of A∗STAR. |
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| This study was presented as an abstract at the Organization for Human Brain Mapping Annual Meeting; June 19-23, 2022; Glasgow, Scotland, UK. |
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| Author Contributions Conceptualization: Nguyen, Zhou Data curation: Nguyen, Qian, Ng, Ong, Ngoh, Yeo, Lau, Tan, Broekman, Law, Gluckman, Chong, Meaney, Zhou Formal analysis: Nguyen, Qian, Ng, Zhou Funding acquisition: Gluckman, Chong, Meaney, Zhou Investigation: Nguyen, Cortese, Zhou Methodology: Nguyen, Zhou Project administration: Ong, Ngoh, Yeo, Lau, Tan, Broekman, Law, Gluckman, Chong, Meaney, Zhou Resources: Nguyen, Ng, Yeo, Lau, Tan, Broekman, Law, Gluckman, Meaney, Zhou Software: Nguyen, Qian, Zhou Supervision: Cortese, Zhou Validation: Nguyen, Zhou Visualization: Nguyen, Zhou Writing – original draft: Nguyen, Zhou Writing – review and editing: Nguyen, Qian, Ng, Ong, Ngoh, Yeo, Lau, Tan, Broekman, Law, Gluckman, Chong, Cortese, Meaney, Zhou |
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| Disclosure: Dr. Ng has received funding from the Ministry of Health, Singapore (MOH-OFYIRG19may-0012). Dr. Cortese has declared honoraria and reimbursement for travel and accommodation expenses for lectures from the following non-profit associations: Association for Child and Adolescent Central Health (ACAMH), Canadian ADHD Alliance Resource (CADDRA), British Association of Pharmacology (BAP), and from Healthcare Convention for educational activity on ADHD. Drs. Qian, Ng, Tan, Broekman, and Law, Sir Gluckman, Drs. Chong, Cortese, Meaney, and Zhou, Ms. Nguyen, Messrs. Ong and Ngoh, and Mss. Yeo and Lau have reported no biomedical financial interests or potential conflicts of interest. |
Vol 63 - N° 1
P. 80-89 - janvier 2024 Retour au numéro
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