More than just methylisothiazolinone: Retrospective analysis of patients with isothiazolinone allergy in North America, 2017-2020 - 11/01/24
, Donglin Zhang, BA a, Srikanth R. Aravamuthan, BS a, Erin M. Warshaw, MD, MS b, c, d, Joel G. DeKoven, MD e, Jonathan I. Silverberg, MD, PhD, MPH f, Brandon L. Adler, MD g, Amber R. Atwater, MD h, James S. Taylor, MD i, Marie-Claude Houle, MD j, Donald V. Belsito, MD k, Jiade Yu, MD l, Nina Botto, MD m, Christen M. Mowad, MD n, Cory A. Dunnick, MD o, p, Vincent A. DeLeo, MD g, Melanie D. Pratt, MD qAbstract |
Background |
Isothiazolinones are a common cause of allergic contact dermatitis.
Objective |
To examine the prevalence of positive patch test reactions to isothiazolinones from 2017-2020 and characterize isothiazolinone-allergic (Is+) patients compared with isothiazolinone nonallergic (Is–) patients.
Methods |
Retrospective cross-sectional analysis of 9028 patients patch tested to methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) 0.02% aqueous, MI 0.2% aqueous, benzisothiazolinone (BIT) 0.1% petrolatum, and/or octylisothiazolinone (OIT) 0.025% petrolatum. Prevalence, reaction strength, concurrent reactions, clinical relevance, and source of allergens were tabulated.
Results |
In total, 21.9% (1976/9028) of patients had a positive reaction to 1 or more isothiazolinones. Positivity to MI was 14.4% (1296/9012), MCI/MI was 10.0% (903/9017), BIT was 8.6% (777/9018), and OIT was 05% (49/9028). Compared with Is–, Is+ patients were more likely to have occupational skin disease (16.5% vs 10.3%, P <.001), primary hand dermatitis (30.2% vs 19.7%, P <.001), and be >40 years (73.1% vs 61.9%, P <.001). Positive patch test reactions to >1 isothiazolinone occurred in 44.1% (871/1976) of Is+ patients. Testing solely to MCI/MI would miss 47.3% (611/1292) of MI and 60.1% (466/776) of BIT allergic reactions.
Limitations |
Retrospective cross-sectional study design and lack of follow-up data.
Conclusion |
Sensitization to isothiazolinones is high and concurrent sensitization to multiple isothiazolinone allergens is common.
Le texte complet de cet article est disponible en PDF.Key words : allergic contact dermatitis, methylisothiazolinone, patch testing
Abbreviations used : ACD, BIT, MCI, MI, NACDG, OIT, PCP
Plan
| Dr Reeder and Ms Zhang contributed equally to this article. |
|
| Funding sources: None. |
|
| IRB approval status: Reviewed and approved by University of Wisconsin IRB (approval #2017-0881-CP007). |
Vol 90 - N° 2
P. 319-327 - février 2024 Retour au numéro
Article précédent
- Melanoma clinicopathological groups characterized and compared with dermoscopy and reflectance confocal microscopy
- Cristina Faldetta, Shaniko Kaleci, Johanna Chester, Cristel Ruini, Silvana Ciardo, Marco Manfredini, Stefania Guida, Camilla Chello, Carmen Cantisani, Jade N. Young, Patricia Cabral, Nicholas Gulati, Emma Guttman-Yassky, Giovanni Pellacani, Francesca Farnetani
- JAAD Game Changer: Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients
- Jane Margaret Grant-Kels
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?