Effects of intraoperative sodium oxybate infusion on post-operative sleep quality in patients undergoing gynecological laparoscopic surgery: A randomized clinical trial - 11/01/24
Abstract |
Study objective |
Post-operative sleep quality is an important factor that influences post-operative recovery. Sodium oxybate has been used to treat sleep disturbances associated with various pathological conditions. However, whether intraoperative intravenous infusion of sodium oxybate improves post-operative sleep quality is unknown. This study aimed to examine the effects of sodium oxybate on the post-operative sleep quality of patients who underwent gynecological laparoscopic surgery.
Design |
A single-center, prospective, two-arm, double-blinded randomized controlled trial.
Setting |
The Shengjing Hospital of China Medical University in Liaoning, China.
Patients |
We enrolled 180 adult patients (90 for each group) undergoing elective gynecological laparoscopic surgery, and 178 patients (89 for each group) were included in the final analysis.
Interventions |
Patients were randomly allocated in a 1:1 ratio to receive either sodium oxybate (30 mg kg−1) or an equivalent volume of saline after intubation. The patients, anesthetists, and follow-up staff were blinded to group assignment.
Measurements |
The primary outcome was sleep quality measured using the Richards–Campbell Sleep Questionnaire (RCSQ) on post-operative days (PODs) one and three. Secondary outcomes included post-operative pain measured using the visual analog scale, sleep quality at one and three months post-operatively measured using the Pittsburgh Sleep Quality Index, and factors associated with post-operative sleep quality.
Main results |
Analysis with generalized estimating equations showed that sodium oxybate significantly improved post-operative sleep quality, as represented by increased total RCSQ scores (mean difference (95% CI); 9 (2, 16), P = 0.010) over PODs one and three. There was no difference in post-operative pain between the two groups over PODs one and three or in post-operative sleep quality over one and three months post-operatively. Age, surgery type, start time of surgery, and use of sufentanil-based patient-controlled intravenous analgesia were significantly associated with post-operative sleep quality.
Conclusions |
Intraoperative sodium oxybate infusion improved post-operative sleep in patients who underwent gynecological laparoscopic surgery.
Trial registration.
Chinese Clinical Trial Registry, Clinical trial number: ChiCTR2200061460.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Post-operative sleep disturbance is commonly seen in surgical population. |
• | Richards-Campbell Sleep Questionnaire scores are validated tools for assessing postoperative sleep quality. |
• | Sodium oxybate improves post-operative sleep quality by reducing nocturnal awakenings and by improving sleep efficiency. |
Keywords : General anesthesia, Gynecological laparoscopic surgery, Post-operative sleep quality, Richards–Campbell sleep questionnaire, Sodium oxybate
Plan
Vol 93
Article 111349- mai 2024 Retour au numéro
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