Delta variant neutralizing antibody response following maternal COVID-19 vaccination - 25/01/24
Doi : 10.1016/j.ajic.2023.09.002
Amanda M. Craig, MD a, ⁎ 
, Carolina G. Pavon, PhD b, Alliyah Byrd, MS b, Kristin Weaver, BS a, Geeta K. Swamy, MD a, Genevieve Fouda, MD PhD b, Brenna L. Hughes, MD a
, Carolina G. Pavon, PhD b, Alliyah Byrd, MS b, Kristin Weaver, BS a, Geeta K. Swamy, MD a, Genevieve Fouda, MD PhD b, Brenna L. Hughes, MD a a Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University, Durham, NC
b Duke Human Vaccine Institute, Duke University, Durham, NC
⁎Address correspondence to Amanada M. Craig, MD, 2608 Erwin Road, Suite 210, Durham, NC 27705.2608 Erwin Road, Suite 210DurhamNC27705
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Résumé |
The Delta pandemic wave saw increased maternal morbidity and mortality compared to prior viral strains. COVID-19 vaccination in pregnancy elicits detectable levels of neutralizing antibodies to SARS-CoV-2 wild type and SARS-CoV-2 Delta variants in both maternal and neonatal samples at delivery. Our results demonstrate the effectiveness of vaccination which confers an immunological response against newer, and potentially more dangerous, viral variants.
Le texte complet de cet article est disponible en PDF.Highlights |
• | All vaccinated individuals had neutralizing antibodies to SARS-CoV-2 wild type. |
• | Most vaccinated individuals had neutralizing antibodies to SARS-CoV-2 Delta variant. |
• | Neutralizing antibodies present in both maternal and neonatal blood at delivery. |
• | COVID-19 vaccination provides maternal protection and passive neonatal immunity. |
Key Words : Pregnancy
Plan
| Funding/support: This study received funding from a private donor and was supported by a Hammond Research Grant from the Duke University Department of Obstetrics and Gynecology. The study protocol was approved by the Duke University Health System IRB #Pro00107883. |
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| Conflicts of interest: None to report. |
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| This work was presented in preliminary form at the Infectious Diseases in Obstetrics and Gynecology 2022 Annual Meeting (August 4-6, 2022; Boston, MA). |
© 2023
Association for Professionals in Infection Control and Epidemiology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 52 - N° 2
P. 252-254 - février 2024 Retour au numéro
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