Serotonin Transporter (5-Hydroxytryptamine Transporter, SERT, SLC6A4) and Sodium-dependent Reuptake Inhibitors as Modulators of Pain Behaviors and Analgesic Responses - 07/02/24
, Andre J. van Wijnen ⁎, ‡ , Hee-Jeong Im ⁎, § Abstract |
The serotonin transporter (5-hydroxytryptamine transporter [5-HTT], Serotonin Transporter (SERT), SLC6A4) modulates the activity of serotonin via sodium-dependent reuptake. Given the established importance of serotonin in the control of pain, 5-HTT has received much interest in studies of pain states and as a pharmacological target for serotonin reuptake inhibitors (SRIs). Animal models expressing varying levels of 5-HTT activity show marked differences in pain behaviors and analgesic responses, as well as many serotonin-related physiological effects. In humans, functional nucleotide variations in the SLC6A4 gene, which encodes the serotonin transporter 5-HTT, are associated with certain pathologic pain conditions and differences in responses to pharmacological therapy. These findings collectively reflect the importance of 5-HTT in the intricate physiology and management of pain, as well as the scientific and clinical challenges that need to be considered for the optimization of 5-HTT-related analgesic therapies.
Perspective |
The serotonin transporter 5-HTT/SCL6A4 is sensitive to pharmacological SRIs. Experimental studies on the physiological functions of serotonin, as well as genetic mouse models and clinical phenotype/genotype correlations of nucleotide variation in the human 5-HTT/SCL6A4 gene, provide new insights for the use of SRIs in chronic pain management.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Serotonin (5-HT) is secreted from pre-synaptic neurons to propagate neurotransmission via receptors in post-synaptic neurons. 5-HT is also recycled via the serotonin transporter (5-HTT) in the synaptic neuron. Inhibition of 5-HTT increases the concentration of 5-HT in the synapse.
Serotonin (5-HT) is secreted from pre-synaptic neurons to propagate neurotransmission via receptors in post-synaptic neurons. 5-HT is also recycled via the serotonin transporter (5-HTT) in the synaptic neuron. Inhibition of 5-HTT increases the concentration of 5-HT in the synapse.ga1Le texte complet de cet article est disponible en PDF.
Highlights |
• | Serotonin levels are controlled by the 5-hydroxytryptamine transporter. |
• | This transporter mediates the reuptake of serotonin in the presynapse. |
• | Pain perception is controlled by serotonin. |
• | Serotonin reuptake inhibitors permit pain management. |
• | Scientific and clinical challenges limit 5-HTT-related analgesic therapies. |
Key Words : Serotonin, serotonin transporter, chronic pain, arthritis, osteoarthritis
Plan
| Address reprint requests to Hee-Jeong Im, Department of Biomedical Engineering, University of Illinois at Chicago, 851S. Morgan St, Chicago, IL. |
Vol 25 - N° 3
P. 618-631 - mars 2024 Retour au numéro
Article précédent
- Acceptance and Commitment Therapy for Chronic Pain: An Overview of Systematic Reviews with Meta-Analysis of Randomized Clinical Trials
- Javier Martinez-Calderon, Cristina García-Muñoz, Carmen Rufo-Barbero, Javier Matias-Soto, Francisco J. Cano-García
- “Buprenorphine, It Works so Differently”: Adults with Sickle Cell Disease Describe Transitioning to Buprenorphine for Treatment of Chronic Pain
- Elizabeth Prince, Paul Loeser, Macy Early, C. Patrick Carroll, Sophie Lanzkron, Lydia H. Pecker
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?