Empirically derived dietary patterns are associated with major adverse cardiovascular events, all-cause mortality, and congestive cardiac failure in older men: The Concord Health and Ageing in Men Project - 21/02/24
, Rosilene Ribeiro c, d, Vasi Naganathan e, f, Fiona Blyth b, g, Louise M Waite e, f, David J Handelsman h, i, David G Le Couteur c, h, Markus J Seibel f, h, Vasant Hirani a, b, c, e, h
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Abstract |
Background |
Diet is associated with major adverse cardiovascular events (MACE).
Objective |
We evaluated the associations between empirically derived dietary patterns and MACE.
Design |
Prospective cohort study.
Setting |
The Concord Health and Ageing in Men Project, Sydney, Australia.
Participants |
539 community-dwelling older Australian men aged 75 years and older.
Methods |
Men underwent dietary assessment using a validated dietitian-administered diet history questionnaire. Cox regression analyses were conducted between MACE and the three dietary patterns identified from factor analysis. Five-point MACE comprised of all-cause mortality, myocardial infarction (MI), congestive cardiac failure (CCF), coronary revascularisation, and/or ischaemic stroke. Four-point MACE included the four endpoints of MI, CCF, coronary revascularisation, and/or ischaemic stroke, and excluded all-cause mortality.
Results |
At a median of 5.3 (IQR 4.6–6.3) years of follow-up, the incidences were: five-point MACE 31.2% (n = 168); four-point MACE excluding all-cause mortality 17.8% (n = 96); all-cause mortality 20.1% (n = 111); CCF 11.3% (n = 61); MI 3.7% (n = 20); stroke 3.2% (n = 17); and coronary revascularisation 3.1% (n = 15). In fully adjusted analyses, compared to the bottom tertile, the middle tertile of ‘vegetables-legumes-seafood’ dietary pattern was associated with reduced five-point MACE (HR 0.67 [95% CI: 0.45, 0.99, P = .047]), and CCF (HR 0.31 [95% CI: 0.15, 0.65, P = .002]), whilst the middle tertile of ‘wholegrains-milk-other fruits’ dietary pattern was associated with increased five-point MACE (HR 1.78 [95% CI: 1.17, 2.70, P = .007]), four-point MACE (HR 1.92 [95% CI: 1.12, 3.30, P = .018]), and CCF (HR 2.33 [95% CI: 1.17, 4.65, P = .016]). For the ‘discretionary-starchy vegetables-processed meats’ dietary pattern, a higher score was associated with increased five-point MACE (HR 1.33 [95% CI: 1.09, 1.62, P = .004]), and all-cause mortality (HR 1.63 [95% CI: 1.26, 2.12, P < .001]), and compared to the bottom tertile, the top tertile was associated with increased all-cause mortality (HR 2.26 [95% CI: 1.27, 4.00, P = .005]).
Conclusion |
Older men may benefit from consuming a ‘vegetables-legumes-seafood’ dietary pattern rather than ‘discretionary-starchy vegetables-processed meats’ and ‘wholegrains-milk-other fruits’ dietary patterns for the prevention of MACE.
Le texte complet de cet article est disponible en PDF.Keywords : Diet, Food, Older men, Mortality, Heart failure, Coronary artery disease
Plan
Vol 28 - N° 2
Article 100020- février 2024 Retour au numéro
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