Prevalence of transfusion-transmitted infections in hospitalized patients before transfusion and volunteer blood donors in Zhejiang Province, China. - 29/02/24
Highlights |
• | Transfusion-transmitted infections (TTIs) have become a major concern, jeopardizing the safe use of blood in clinical practice. |
• | We assessed TTI seroprevalence in hospitalized patients and voluntary blood donors in Zhejiang Province. |
• | Positive blood cultures pose a risk to the health of blood recipients with low immunity, and seriously compromise the safe use of blood in clinical practice. |
• | Expanding the pathogen categories of blood screening programs and adopting scientifically sound transfusion methods could improve blood quality and ensure blood safety. |
Abstract |
Objectives |
To assess the need for screening of transfusion-transmitted infections (TTIs) in blood products, we assessed TTI seroprevalence in blood donors and hospitalized patients.
Methods |
We collected 2760 serum samples from three regions of Hangzhou, Ningbo and Huzhou from April 2021 to March 2022, and they tested by enzyme-linked immunosorbent assay (ELISA) for Hepatitis B surface antigen (HBsAg), Hepatitis C (HCV), Treponema pallidum (TP), Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Hepatitis E virus (HEV) and Human T-cell lymphotropic virus type 1/2 (HTLV-1/2) antibody levels.
Results |
Screening test results showed that the positive rates for HBsAg, anti-HCV and anti-TP were 3.01 %, 0.39 % and 0.18 %, respectively. The positive rates for CMV IgM and CMV IgG were 0.76 % and 96.96 %, while the positive rates for EB VCA-IgM and EB EA-IgG were 1.88 % and 10.47 %; those for HEV IgM and HEV IgG were 1.16 % and 26.05 %, while the HTLV-1/2 antibody positive rate was 0.04 %. The positive rates for CMV IgG, EB EA-IgG and HEV IgG in hospitalized patients before transfusion were higher than in volunteer blood donors, and the difference was statistically significant (P < 0.05). The overall co-infection rate was 0.29 %. The positive rates for EB VCA-IgM in the males were significantly higher than in females, and EB VCA-IgM and HEV IgG prevalence varied significantly by age.
Conclusion |
Our data demonstrate the risk of TTI exposure and TTI transmission in the Zhejiang population, which poses a threat to blood safety. It is hoped that expansion of pathogen categories (CMV, EBV, HEV and HTLV-1/2) and blood screening programs will contribute to the future adoption of scientific blood transfusion methods.
Le texte complet de cet article est disponible en PDF.Keywords : Transfusion-transmitted infections, CMV, EBV, HEV, HTLV-1/2
Plan
Vol 54 - N° 2
Article 104861- mars 2024 Retour au numéro
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