Retinal and Choroidal Vascularity Evaluation in Pediatric Radiologically Isolated Syndrome and Multiple Sclerosis - 08/03/24
: Assistant Professor, Sena Destan Bünül, MD b : Assistant Professor, Bülent Kara, MD c : Professor, Defne Alikılıç, MD c, Levent Karabaş, MD a : Professor, Hüsnü Efendi, MD b : Professor, Nurşen Yüksel, MD a : ProfessorAbstract |
Background |
To assess vessel density (VD) and flow of retinal plexuses and peripapillary region related with the pediatric radiologically isolated syndrome (RIS) and multiple sclerosis (MS).
Methods |
We analyzed 24 eyes of 12 participants with the diagnosis of RIS, 24 eyes of 12 participants with the diagnosis of MS, and 26 eyes of 13 age- and sex-matched healthy controls in this prospective, cross-sectional study. The superficial capillary plexus (SCP) and deep capillary plexus, foveal avascular zone, and the flow of choriocapillaris were investigated using optical coherence tomography angiography.
Results |
Parafoveal VD and all subregion parameters in SCP were significantly decreased in the MS group compared with the controls, whereas only nasal and inferior VD were significantly decreased in the pediatric RIS group compared with the controls. Ganglion cell layer (GCL) thickness of all subregions of the inner ring was significantly decreased in the pediatric MS group compared with the control group. No significant difference was observed between the pediatric RIS group and the control group regarding thickness.
Conclusions |
We showed lower parafoveal VD in all subregions of SCP in pediatric MS, whereas only parafoveal nasal and inferior VD were decreased in pediatric RIS. GCL thickness of inner ring was significantly decreased in the pediatric MS, whereas GCL thickness did not change in pediatric RIS. Therefore, a decrease of parafoveal nasal and inferior VD without a decrease in thickness implies an early impairment of microvasculature in the RIS before impairment of thickness and that microvascular alterations begin from highly vascular superficial parafovea.
Le texte complet de cet article est disponible en PDF.Keywords : Optical coherence tomography angiography, Radiologically isolated syndrome, Multiple sclerosis, Superficial capillary plexus, Parafoveal vessel density
Plan
| Funding: No funding was received for conducting this study. |
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| Disclosures: No financial disclosures. |
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| Availability of data: Data available on request. |
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| Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Local ethics committee registration number of this study is GOKAEK-2022/01.08. |
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| Informed consent: Written informed consent was obtained from all individual participants included in the study. |
Vol 153
P. 34-43 - avril 2024 Retour au numéro
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