Correlation between catheter colonization of central venous catheters and clinical biochemical indicators: A retrospective analysis of the MIMIC‑IV database - 18/03/24
Résumé |
Background |
Clinical studies have not fully assessed the potential impact of patients’ biochemical indicators on the rate of positive for central venous catheter-tip microorganism culture (PCMC).
Methods |
Data were obtained from an online Medical Information Mart for Intensive Care IV database. Patients who were ≥18 years old and had central venous catheter-tip culture results without continuous renal replacement therapy were included in the study. A comparison of patient characteristics and their biochemical indicators was made between negative and positive culture results.
Results |
A total of 5,323 patients were included in the analysis, including 612 positive (PCMC group) and 4,711 negative culture results (negative for central venous catheter tip catheter-tip microorganism culture [NCMC] group). The only influence factor on PCMC in this study was the serum creatinine (Scr) (odds ratio: 1.312, 95% confidence interval: 1.084-1.590, P = .005), according to a binary logistic regression analysis. The cut-off value of Scr was 3.25 mg/dL. The prevalence of PCMC (27.1% vs 9.1%, P < .001) and Staphylococcus aureus (43.0% vs 18.6%, P < .001) for central venous catheter-tip culture results was much higher in patients with Scr ≥ 3.25 mg/dL than those Scr < 3.25 mg/dL.
Conclusions |
We used the large dataset collected from Medical Information Mart for Intensive Care IV to show that patients with Scr ≥ 3.25 mg/dL had an increased risk for PCMC.
Le texte complet de cet article est disponible en PDF.Highlights |
• | High serum creatinine was correlated with the positive of CVC-tip culture. |
• | The cut-off value of serum creatinine was 3.25 mg/dL. |
• | The prevalence of S aureus for PCMC was higher with Scr≥3.25 mg/dL. |
Key Words : Intensive care units, Bacterial colonization, Serum creatinine, Staphylococcus aureus
Plan
| Conflicts of interest: None to report. |
|
| Funding/support: This research was supported by Zhejiang Provincial Natural Science Foundation of China (Grant No. LY19H190001); Medical Scientific Research Foundation of Zhejiang Province, China (Grant No.2018KY688); Ningbo Medical Key Supported Discipline, China (Grant No.2022-F16). |
Vol 52 - N° 4
P. 450-455 - avril 2024 Retour au numéro
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