Zinc supplementation is associated with improvement in hand-foot skin reaction in patients on vascular endothelial growth factor receptor-tyrosine kinase inhibitors: A cohort study - 20/03/24
Doi : 10.1016/j.jaad.2023.11.054
Chun-Wei Lu, MD a, b, c, Chun-Nan Yeh, MD d, Hung-Chih Hsu, MD, PhD e, Chun-Bing Chen, MD a, b, c, Tsai-Sheng Yang, MD e, Yi-Ru Pan, PhD d, Wen-Hung Chung, MD, PhD a, b, c, ⁎ 
, Shuen-Iu Hung, PhD f, g, ⁎
, Shuen-Iu Hung, PhD f, g, ⁎ a Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan
b Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan
c Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
d Department of General Surgery, GIST team, and Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Chang Gung University, Taoyuan, Taiwan
e Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou Branch, College of Medicine, Chang Gung University, Taoyuan, Taiwan
f Cancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan
g Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei, Taiwan
∗Correspondence to: Wen-Hung Chung, MD, PhD, Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, No 5, Fuxing St, Guishan Dist, Taoyuan, 333, TaiwanDepartment of DermatologyChang Gung Memorial Hospital, Linkou BranchNo 5, Fuxing StGuishan DistTaoyuan333Taiwan∗∗Shuen-Iu Hung, PhD, Department of Medical Research, Research building 6F, Chang Gung Memorial Hospital, Linkou Branch, No 5, Fuxing St, Guishan Dist, Taoyuan, 333, TaiwanDepartment of Medical ResearchResearch building 6FChang Gung Memorial Hospital, Linkou BranchNo 5, Fuxing StGuishan DistTaoyuan333Taiwan
Key words : cutaneous adverse reactions, hand-foot skin reaction (HFSR), multikinase inhibitors (MKI), vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs), zinc supplementation, zinc
| Funding sources: H.C.H. has received grants from the National Science and Technology Council, Taiwan (NSTC 110-2314-B-182A-094), and Chang Gung Memorial Hospital (CMRPG3K2201∼2, CIRPG3K0021∼2). W.H.C. has received grants from the National Science and Technology Council, Taiwan (NSTC 111-2326-B-182A-003-, 111-2314-B-182A-113 -MY3, 112-2326-B-182A-001-), and Chang Gung Memorial Hospital (CORPG3L0471-3 and OMRPG3N0011). S.I.H. has received grants from the National Science and Technology Council, Taiwan (NSTC 112-2320-B-182A-006-MY3), and Chang Gung Memorial Hospital (CLRPG3N0021). |
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| Patient consent: All patients gave consent for their medical information to be published. |
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| IRB approval status: The study was reviewed and approved by the Institutional Review Board of Chang Gung Memorial Hospital Linkou branch (IRB No. 201600897A3, 201902171A3). |
© 2023
American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 90 - N° 4
P. 814-815 - avril 2024 Retour au numéro
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