MR Imaging-based Biomarker Development in Hemorrhagic Stroke Patients Including Brain Iron Quantification, Diffusion Tensor Imaging, and Phenomenon of Ultra-early Erythrolysis - 09/04/24

Doi : 10.1016/j.nic.2024.01.001

Momodou G. Bah, MPH ^a, Ehsan Dowlati, MD ^b, Max Fleigner, BS ^c, Sravanthi Koduri, MD ^b, Aditya Pandey, MD ^b,^d, Leanne Y. Lin, MD, MPHS ^d, Thomas L. Chenevert, PhD ^d, Jonathan Troost, PhD ^e, Guohua Xi, MD ^b, Richard Keep, PhD ^b, Neeraj Chaudhary, MD ^b,^d,^f,^⁎
^a Michigan State University College of Human Medicine, Lansing, MI, USA
^b Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA
^c Oakland University, William Beaumont School of Medicine, Detroit, MI, USA
^d Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA
^e Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48109, USA
^f Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109, USA

^∗Corresponding author. Department of Radiology, Michigan Medicine, 1500 E Medical Center Drive, Ann Arbor, MI 48109.Department of RadiologyMichigan Medicine1500 E Medical Center DriveAnn ArborMI48109

Résumé

This review article discusses the role of MR imaging-based biomarkers in understanding and managing hemorrhagic strokes, focusing on intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage. ICH is a severe type of stroke with high mortality and morbidity rates, primarily caused by the rupture of small blood vessels in the brain, resulting in hematoma formation. MR imaging-based biomarkers, including brain iron quantification, ultra-early erythrolysis detection, and diffusion tensor imaging, offer valuable insights for hemorrhagic stroke management. These biomarkers could improve early diagnosis, risk stratification, treatment monitoring, and patient outcomes in the future, revolutionizing our approach to hemorrhagic strokes.

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Keywords : MR imaging biomarkers, ICH, SAH, Iron toxicity, Hematomal and perihematomal iron concentration, White matter injury, Early erythrolysis, Early and late brain injury

Plan

Key points

Introduction

Role of iron in hemorrhagic stroke

Techniques for brain iron quantification

Brain iron quantification in intracerebral hemorrhage

Imaging Characteristics of a Hematoma on MR Imaging

Perihematomal Iron Quantification Techniques on MR Imaging

Ultra-early erythrolysis in intracerebral hemorrhage on MR imaging

Definition and Characteristics of Ultra-early Erythrolysis

Imaging Findings and MR Imaging Features of Early Erythrolysis

Diffusion tensor imaging in intracerebral hemorrhage

Brain iron quantification in aneurysmal subarachnoid hemorrhage

Quantitative Assessment of Iron in Patients with Aneurysmal Subarachnoid Hemorrhage

Use of Diffusion Tensor Imaging in Patients with Aneurysmal Subarachnoid Hemorrhage

Clinical applications and future perspectives

Summary

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Funding

Ethics approval for case report

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Vol 34 - N° 2

P. 215-224 - mai 2024 Retour au numéro

Article précédent

MR Imaging Techniques for Acute Ischemic Stroke and Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage
Marco Colasurdo, Huanwen Chen, Dheeraj Gandhi

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MR Imaging-based Biomarker Development in Hemorrhagic Stroke Patients Including Brain Iron Quantification, Diffusion Tensor Imaging, and Phenomenon of Ultra-early Erythrolysis - 09/04/24

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