Predicting Preterm Birth Using Cell-Free Ribonucleic Acid - 03/05/24

Doi : 10.1016/j.clp.2024.02.008

Alison D. Cowan, MD, MSCR ^a,^⁎ , Morten Rasmussen, PhD ^b, Maneesh Jain, PhD ^c, Rachel M. Tribe, PhD ^d
^a Department of Medical Affairs, Mirvie, Inc., 651 Gateway Boulevard, Suite 1200, South San Francisco, CA 94080, USA
^b Department of Research and Development, Mirvie, Inc., 651 Gateway Boulevard, Suite 1200, South San Francisco, CA 94080, USA
^c Mirvie, Inc., 651 Gateway Boulevard, Suite 1200, South San Francisco, CA 94080, USA
^d Department of Women and Children’s Health, School of Life Course and Population Sciences, King’s College London, St. Thomas's Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK

^∗Corresponding author. 651 Gateway Boulevard, Suite 1200, South San Francisco, CA 94080.651 Gateway Boulevard, Suite 1200South San FranciscoCA94080

Résumé

Spontaneous preterm birth (sPTB) is a complex and clinically heterogeneous condition that remains incompletely understood, leading to insufficient interventions to effectively prevent it from occurring. Cell-free ribonucleic acid signatures in the maternal circulation have the potential to identify biologically relevant subtypes of sPTB. These could one day be used to predict and prevent sPTB in asymptomatic individuals, and to aid in prognosis and management for individuals presenting with threatened preterm labor and preterm prelabor rupture of membranes.

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Keywords : Cell-free RNA, Transcriptomics, Screening model, Etiology, Spontaneous preterm birth, Preterm prelabor rupture of membranes, Cervical insufficiency