Improved sexual function after parathyroidectomy in women with primary hyperparathyroidism - 11/05/24

Doi : 10.1016/j.amjsurg.2023.11.002

Hui Zheng ^a,^⁎ , Victoria Lai ^a, Jana Lu ^b, Kenneth D. Burman ^c, Leonard Wartofsky ^d, Jennifer E. Rosen ^a
^a MedStar-Washington Hospital Center, Division of Endocrine Surgery, 110 Irving St NW, Washington, DC, 20010, USA
^b Georgetown University School of Medicine, 3900 Reservoir Rd NW, Washington, DC, 20007, USA
^c MedStar-Washington Hospital Center, Section of Endocrinology, 110 Irving St NW, Washington, DC, 20010, USA
^d MedStar Health Research Institute, Thyroid Cancer Unit, 100 Irving St NW, Washington, DC, 20010, USA

^∗Corresponding author. MedStar-Washington Hospital Center, Division of Endocrine Surgery, 106 Irving St NW, POB 2200, North Washington, DC, 20010, USA.MedStar-Washington Hospital CenterDivision of Endocrine Surgery106 Irving St NWPOB 2200North WashingtonDC20010USA

Abstract

Background

The study aimed to evaluate whether women with primary hyperparathyroidism (PHPT) experience improvement in their sexual function after parathyroidectomy.

Methods

Women with PHPT or benign thyroid nodules (controls) undergoing surgery were administered the validated Parathyroidectomy Assessment Score (PAS), Patient-Reported Outcomes Measurement Information System-29 (PROMIS-29) and Female Sexual Function Index (FSFI) pre-operatively, at 3 months and 6 months postoperatively.

Results

Of the 26 PHPT and 18 control patients, PHPT patients were older (53.1 vs 45.3 years, p = 0.008). Post-operatively, both PHPT (pre-op 2.4 vs 3-month 3.0 vs 6-month 2.4, p = 0.022) and control patients (pre-operative 2.4 vs 3-month 3.3 vs 6-month 3.6, p = 0.032) reported increased desire for sexual activities. In addition, PHPT patients experienced increased arousal (pre-operative 2.7 vs 3-month 3.9 vs 6-month 3.6, p = 0.047) and satisfaction (pre-operative 3.0 vs 3-month 4.8 vs 6-month 4.0, p = 0.006).

Conclusions

The current study indicates that women with PHPT may experience improved sexual function after parathyroidectomy.

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Highlights

•	Female sexual function in the context of PHPT is understudied.
•	Mood alterations associated with PHPT can adversely affect sexual function.
•	Women with PHPT may have improved sexual function after surgery.
•	Larger well-controlled studies are needed to further assess this relationship.

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Keywords : Primary hyperparathyroidism, Female sexual dysfunction, Quality of life (QoL)