Association between lymph node ratio and survival outcomes in patients with oral squamous cell carcinoma - 25/05/24
, Manabu Habu a, Osamu Takahashi a, Kazuhiro Tominaga b, Izumi Yoshioka c, Masaaki Sasaguri aHighlights |
• | Lymph node ratio (LNR) may represent a prognostic indicator in oral squamous cell carcinoma (OSCC) with cervical lymph node metastasis. |
• | LNR is suggested to be a reliable marker in predicting the prognosis of OSCC. |
• | LNR may serve as an index for examining whether adjuvant therapy is necessary to improve prognosis of OSCC patients. |
• | Establishing an optimal LNR cutoff value for predicting prognosis in OSCC cases requirs further research. |
Abstract |
Background |
Recent reports have shown that the Lymph node ratio (LNR) is useful for predicting the prognosis in some cancers, however there are few reports on the usefulness of LNR in predicting the prognosis of oral squamous cell carcinoma (OSCC). The predictive value of LNR for prognosis of OSCC was investigated.
Materials and methods |
The study included 152 patients with OSCC and histologically confirmed cervical lymph node metastasis who underwent neck dissection. We analyzed the relationship between LNR and overall survival (OS) and recurrence-free survival (RFS) retrospectively in these cases, with the relationship between prognosis and clinicopathological findings also examined.
Results |
Using a receiver operating characteristics curve, the LNR cutoff value was set at 0.095, categorizing 64 and 88 cases into high LNR (≥ 0.095) and low LNR (< 0.095) groups, respectively. Regarding OS and RFS, the prognosis was significantly worse in the high LNR group compared with the low LNR group. In multivariate analysis, sex, postoperative nodal stage, and LNR merged as independent prognostic factors.
Conclusion |
This study's findings suggest that LNR may represent a prognostic indicator in OSCC with cervical lymph node metastasis.
Le texte complet de cet article est disponible en PDF.Keywords : Oral squamous cell carcinoma, Lymph node ratio, Survival outcomes, Cervical lymph node metastasis, Neck dissection
Plan
Vol 125 - N° 3S
Article 101816- juin 2024 Retour au numéro
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