Interstitial Lung Abnormalities : Current Understanding - 28/05/24

Doi : 10.1016/j.ccm.2024.02.013

Noriaki Wada, MD ^a,^{^{1
iPNet; image-based Phenotyping Network.}}, Gary M. Hunninghake, MD, MPH ^a,^b,^{^{1
iPNet; image-based Phenotyping Network.}}, Hiroto Hatabu, MD, PhD, FACR ^a,^⁎,^{^{1
iPNet; image-based Phenotyping Network.}}
^a Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
^b Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

^∗Corresponding author.

Résumé

Interstitial lung abnormalities (ILAs) are incidental findings on computed tomography scans, characterized by nondependent abnormalities affecting more than 5% of any lung zone. They are associated with factors such as age, smoking, genetic variants, worsened clinical outcomes, and increased mortality. Risk stratification based on clinical and radiological features of ILAs is crucial in clinical practice, particularly for identifying cases at high risk of progression to pulmonary fibrosis. Traction bronchiectasis/bronchiolectasis index has emerged as a promising imaging biomarker for prognostic risk stratification in ILAs. These findings suggest a spectrum of fibrosing interstitial lung diseases, encompassing from ILAs to pulmonary fibrosis.

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Keywords : Interstitial lung abnormalities, Pulmonary fibrosis, Interstitial lung disease, Risk stratification, Traction bronchiectasis/bronchiolectasis index, Clinical management