Association between N-terminal pro-brain natriuretic peptide and maximal functional capacity in heart failure with preserved ejection fraction: The modifying role of obesity - 04/07/24

Doi : 10.1016/j.orcp.2024.05.005

Patricia Palau ^a,^⁎,^{^{1
Both authors contributed equally.}} , Gonzalo Núñez ^a,^{^{1
Both authors contributed equally.}}, Rafael de la Espriella ^a, Gema Miñana ^a,^e, Eloy Domínguez ^a,^b, Miguel Lorenzo ^a, Laura López ^a,^c, Cristina Flor ^c, Paloma Marín ^a,^d, Antoni Bayés-Genís ^f, Juan Sanchis ^a,^e, Julio Núñez ^a,^e,^⁎
^a Cardiology Department, Hospital Clínico Universitario, INCLIVA, Universitat de València, Valencia, Spain
^b Universitat Jaume I, Castellón, Spain
^c Facultad de Fisioterapia, Universitat de València, Valencia, Spain
^d Facultad de Enfermería, Universitat de València, Valencia, Spain
^e CIBER Cardiovascular, Spain
^f Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain

^⁎Correspondence to: Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Av. de Blasco Ibáñez, 17, 46010 Valencia, Spain.Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de ValenciaAv. de Blasco Ibáñez, 17Valencia46010Spain

Abstract

This study investigates the association between maximal functional capacity (peakVO₂) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in 133 ambulatory patients with heart failure with preserved ejection fraction (HFpEF), focusing on patients with obesity. Across all participants, NT-proBNP inversely correlated with peakVO₂. However, this association varied based on obesity status. In patients without obesity, there was an inverse relationship between NT-proBNP and peakVO₂, while no significant correlation was observed in patients with obesity. These findings suggest that in stable ambulatory HFpEF, NT-proBNP did not predict peakVO₂ in patients with obesity.

Le texte complet de cet article est disponible en PDF.

Highlights

•	Higher NT-proBNP levels were significantly but marginally associated with lower peakVO₂ in symptomatic patients with HFpEF.
•	The association between NT-proBNP and peakVO₂ largely differed across obesity, being non-significant in patients with obesity.
•	These findings endorse the limitations of natriuretic peptides in assessing patients with HFpEF and obesity.

Le texte complet de cet article est disponible en PDF.

Abbreviations : BMI, CPET, HFpEF, NT-proBNP, PeakVO₂

Keywords : HFpEF, Maximal functional capacity, PeakVO₂, NT-proBNP, Obesity

Plan

Introduction

Methods

Study sample and procedures

Biomarkers and body mass index assessment

Statistical analysis

Results

Baseline characteristics

Relationship between maximal exercise capacity and NT-proBNP

NT-proBNP and functional capacity: the role of obesity

CRediT authorship contribution statement

Export

Vol 18 - N° 3

P. 226-231 - mai 2024 Retour au numéro

Article précédent

Intrapartum antibiotic use is associated with higher child body mass index (BMI) z-score at 4 years of age
Nicole A. Cho, Gerald F. Giesbrecht, Deborah Dewey, Raylene A. Reimer

| Article suivant

Approach to duodenal pathology in bariatric surgery: Transit bipartition as an option
Sergi Sanchez-Cordero, Ruth Lopez-Gonzalez, Jordi Pujol-Gebellí, Jordi Castellvi-Valls

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Association between N-terminal pro-brain natriuretic peptide and maximal functional capacity in heart failure with preserved ejection fraction: The modifying role of obesity - 04/07/24

Abstract

Highlights

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL