Immunogenicity of BNT162b2 as a first booster after a ChAdOx1 primary series in a Thai geriatric population living with frailty - 18/07/24
, Kulkanya Chokephaibulkit b, c , Chatkamol Pheerapanyawaranun b , Zheng Quan Toh d, e , Paul V. Licciardi d, e , Arpa Satayasanskul g , Laddawan Jansarikit a , Prasert Assantachai f, ⁎
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Abstract |
Objectives |
Impact of frailty towards immunogenicity and reactogenicity of BNT162b2 boosters administered via intramuscular or intradermal routes in a Thai geriatric population
Design |
Prospective, randomized, open-labeled.
Setting |
Siriraj Hospital, Thailand.
Participants |
Geriatric adults aged ≥65 years.
Intervention |
10 μg intradermal or 30 μg intramuscular BNT162b2 (Pfizer-BioNTech).
Measurements |
Anti-SARS-CoV-2 receptor binding domain IgG, neutralizing antibodies (NAb), and interferon-gamma producing cells against Wuhan and Omicron BA.4/5. Analyses were stratified based on participants’ Clinical Frailty Scale.
Results |
A total of 139 participants were included in the analysis. Two-four weeks post-booster administration, NAb titers against Wuhan but not Omicron BA.4/5 were significantly lower among frail participants than non-frail participants who received intramuscular administration. Spike-specific T cell responses were similar for frail and non-frail participants, regardless of administration route. Frail participants who received intradermal BNT162b2 had fewer local adverse events (AEs), but higher systemic AEs than non-frail participants.
Conclusion |
Similar immune responses across vaccine routes warrants further evaluation of intradermal BNT162b2 in frail geriatric populations. Frail participants may be more sensitive to reporting systemic AEs.
Registration of clinical trials |
The parent study was registered under the Thai Clinical Trials Registry (TCTR20220112002).
Le texte complet de cet article est disponible en PDF.Keywords : Frailty, Geriatric, COVID-19 vaccines, Immunogenicity, Thailand
Abbreviations : anti-RBD, AU, BAU, CFS, GMU, GMC, GMT, IADL, IFN-γ, LOD, Nab, NRS, PVNT, PVNT50, RBD, S
Plan
Vol 28 - N° 8
Article 100315- août 2024 Retour au numéro
Article précédent
- Cross-sectional and longitudinal associations of adherence to WCRF/AICR cancer prevention recommendations with health-related quality of life in breast cancer survivors. Health-EpiGEICAM study
- Virginia Lope, Ángel Guerrero-Zotano, Nerea Fernández de Larrea-Baz, Silvia Antolín, Marta Benavent Viñuales, Begoña Bermejo, Emma Ruiz-Moreno, José Manuel Baena-Cañada, Lorena París, Antonio Antón, José Ignacio Chacón, Montserrat Muñoz, José Angel García-Sáenz, Clara Olier, Pedro Sánchez Rovira, Angels Arcusa Lanza, Sonia González, Joan Brunet, Amparo Oltra, Susana Bezares, Libertad Rosell, Beatriz Pérez-Gómez, Roberto Pastor-Barriuso, Miguel Martín, Marina Pollán
- The association between sarcopenia index and cognitive function among stroke survivors
- Xiao-Ming Zhang, Wei Liu, Jin-Feng Zhang, Xiao-Hua Xie, Chen-Yun Liu, Cong-Hua Wang
Bienvenue sur EM-consulte, la référence des professionnels de santé.