Wound colonization with methicillin-resistant Staphylococcus aureus and hypotheses about acquisition routes in rural health care settings in Sub-Saharan Africa: Perspective from a center devoted to the treatment of cutaneous neglected tropical diseases - 20/07/24

Doi : 10.1016/j.ajic.2024.05.007

Thomas Nicol, MD ^a,^b, Charles Declerck, MD ^c, Morgane Le Gallo, MD ^d, Camille Bougeard, PharmD ^b, Akimat Habib, MD ^e, Périn Catraye, MD ^e, Ambroise Adeye, MD ^e, Alexandra Boccarossa, PhD ^a, Vincent Dubée, MD, PhD ^a,^c, Laurent Marsollier, PhD ^a, Estelle Marion, PhD ^a, Roch Christian Johnson, MD, PhD ^e,^f,^{^{1
Matthieu Eveillard and Roch Christian Johnson contributed equally to this work.}}, Matthieu Eveillard, PharmD, PhD ^a,^b,^⁎,^{^{1
Matthieu Eveillard and Roch Christian Johnson contributed equally to this work.}}
^a Université Angers, Nantes Université, CHU Angers, Inserm, CNRS, INCIT, Angers, France
^b Laboratoire de Bactériologie, Département de Biologie des Agents Infectieux, CHU Angers, Angers, France
^c Service des Maladies Infectieuses et Tropicales, CHU Angers, Angers, France
^d Pôle Biologie, CHU Angers, Angers, France
^e Centre de Diagnostic et de Traitement de la Lèpre et de l'Ulcère de Buruli – Raoul Follereau Foundation, Pobè, Benin
^f Centre Interfacultaire de Formation et de Recherche en Environnement pour le Développement Durable, Université d’Abomey-Calavi, Abomey-Calavi, Benin

^⁎Address correspondence to Matthieu Eveillard, PharmD, PhD, Laboratoire de Bactériologie, Département de Biologie des Agents Infectieux, CHU Angers, Angers, France.Laboratoire de Bactériologie, Département de Biologie des Agents Infectieux, CHU AngersAngersFrance

Résumé

We identified a high prevalence (46.4%) of wound colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients hospitalized in a center devoted to the treatment of cutaneous tropical diseases in Benin. The proportion of MRSA among S aureus isolates was 54.3%. Thirty percent of these MRSA were identified in outpatients. The analysis of pulsed-field gel electrophoresis demonstrated an important diversity of strains but also identified 8 small clusters containing between 2 and 4 isolates suggesting cross-transmission.

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Highlights

•	Almost half of patients’ wounds were colonized with MRSA.
•	Total 30% of MRSA were identified in outpatients.
•	Diversity of MRSA isolates according to pulsed-field gel electrophoresis.
•	Several small clusters suggest direct or cross-transmission inside the center.
•	Need for rural African health care settings to refer to a microbiology laboratory.

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Key Words : Wounds, Cross-transmission, Prevalence, Low resources, Clinical microbiology laboratory, MRSA

Plan

	Conflicts of interest: None to report.
	Funding/support: This study was supported by a scientific grant (2022) from the Fondation Raoul Follereau France.

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Vol 52 - N° 8

P. 977-980 - août 2024 Retour au numéro

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Wound colonization with methicillin-resistant Staphylococcus aureus and hypotheses about acquisition routes in rural health care settings in Sub-Saharan Africa: Perspective from a center devoted to the treatment of cutaneous neglected tropical diseases - 20/07/24

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