Initial report on the multiple biological and pharmacological properties of hispolon: Exploring stochastic mechanisms - 23/07/24

Doi : 10.1016/j.biopha.2024.117072

Tarik Aanniz ^a,^{^{1
Both authors contributed equally to this work.}}, Ikrame Zeouk ^b, Youssef Elouafy ^c, Jihane Touhtouh ^d, Rym Hassani ^e, Khalil Hammani ^d, Taoufiq Benali ^f, Mohamed El-Shazly ^g,^h, Asaad Khalid ^i,^j,^⁎ , Ashraf N. Abdalla ^k, Sara Aboulaghras ^l, Khang Wen Goh ^m, Long Chiau Ming ⁿ, Pakhrur Razi ^o,^⁎ , Saad Bakrim ^p, Abdelhakim Bouyahya ^l,^⁎,^{^{1
Both authors contributed equally to this work.}}

^a Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical and Pharmacy School, Mohammed V University, Rabat, Morocco

^b Laboratoire de Pharmacologie, Toxicologie, Faculté de Médecine, de Pharmacie et de Médecine dentaire de Fès, Université Sidi Mohamed Ben Abdellah, Morocco

^c Laboratory of Materials, Nanotechnology and Environment LMNE, Faculty of Sciences, Mohammed V University in Rabat, Rabat BP 1014, Morocco

^d Laboratory of Natural Resources and Environment, Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez, B.P. 1223 Taza-Gare, Taza, Morocco

^e Biology Department, University College AlDarb, Jazan University, Jazan 45142, Saudi Arabia

^f Environment and Health Team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Safi 46030, Morocco

^g Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt

^h Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, The German University in Cairo, Cairo 11432, Egypt

ⁱ Substance Abuse and Toxicology Research Center, Jazan University, P.O. Box: 114, Jazan 45142, Saudi Arabia

^j Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, P. O. Box 2404, Khartoum, Sudan

^k Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia

^l Laboratory of Human Pathologies Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10106, Morocco

^m Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia

ⁿ School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia

^o Center of Disaster Monitoring and Earth Observation, Universitas Negeri Padang, Padang, Indonesia

^p Geo-Bio-Environment Engineering and Innovation Laboratory, Molecular Engineering, Biotechnology and Innovation Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir 80000, Morocco

^⁎ Corresponding author at: Substance Abuse and Toxicology Research Center, Jazan University, P.O. Box: 114, Jazan 45142, Saudi Arabia. Substance Abuse and Toxicology Research Center, Jazan University P.O. Box: 114 Jazan 45142 Saudi Arabia ^⁎⁎ Corresponding authors.

Abstract

The development of natural substances derived from nature poses a significant challenge as technologies for the extraction and characterization of active principles advance. Hispolon has received a lot of attention in recent years, ascribable to its wide range of biological activities. It is a phenolic molecule that was extracted from several mushroom species such as Phellinus igniarius , Phellinus linteus, Phellinus lonicerinus , Phellinus merrillii , and Inonotus hispidus . To provide a comprehensive overview of the pharmacological activities of hispolon, this review highlights its anticancer, anti-inflammatory, antioxidant, antibacterial, and anti-diabetic activities. Several scientific research databases, including Google Scholar, Web of Science, PubMed, SciFinder, SpringerLink, Science Direct, Scopus, and, Wiley Online were used to gather the data on hispolon until May 2024. The in vitro and in vivo studies have revealed that hispolon exhibited significant anticancer properties through modifying several signaling pathways including cell apoptosis, cycle arrest, autophagy, and inhibition of angiogenesis and metastasis. Hispolon's antimicrobial activity was proven against many bacterial, fungal, and viral pathogens, highlighting its potential use as a novel antimicrobial agent. Additionally, hispolon displayed potent anti-inflammatory activity through the suppression of key inflammatory mediators, such as inducible NO synthase (iNOS), tumor necrosis factor-α (TNF-α), and cyclooxygenases-2 (COX-2), and the modulation of mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways. The antioxidant potential of hispolon was attributed to its capacity to neutralize reactive oxygen species (ROS) and to increase the activity of antioxidant enzymes, indicating a possible involvement in the prevention of oxidative stress-related illnesses. Hispolon's antidiabetic activity was associated with the inhibition of aldose reductase and α-glucosidase. Studies on hispolon emphasized its potential use as a promising scaffold for the development of novel therapeutic agents targeting various diseases, including cancer, infectious diseases, inflammatory disorders, and diabetes.

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Highlights

•	Hispolon has been characterized in several different mushroom species.
•	Hispolon has been known as anticancer, anti-inflammatory, and antimicrobial properties.
•	The reported studies about chemical characterization and properties of hispolon have been discussed in this review.
•	The main anticancer mechanisms of hispolon are the induction of apoptosis and cell cycle arrest, as well as inhibition of autophagy, and metastasis.

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Keywords : Cancer, Anticancer, Infectious disease, Communicable disease, Anti-inflammatory, Cell cycle arrest, Diabetes mellitus

Plan

Introduction

Research methodology

Natural sources and chemical characterization

Biological activities and pharmacological properties

Anticancer activity

Anti-inflammatory activity

Antioxidant activity

Antidiabetic activity

Neurological protection

Antimicrobial activity

Safety and toxicology of hispolon sources

Limitations and future directions

Conclusions and future perspectives

Funding

CRediT authorship contribution statement

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Article 117072- août 2024 Retour au numéro

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Initial report on the multiple biological and pharmacological properties of hispolon: Exploring stochastic mechanisms - 23/07/24

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