Neonatal Encephalopathy is a Complex Phenotype Representing Reproductive and Pregnancy Exposome Effects on the Maternal-Placental-Fetal Triad - 01/08/24
Résumé |
Reproductive, pregnancy, and placental exposomes influence the fetal neural exposome through toxic stressor interplay, impairing the maternal-placental-fetal (MPF) triad. Neonatal encephalopathy represents different clinical presentations based on complex time-dependent etiopathogenetic mechanisms including hypoxia-ischemia that challenge diagnosis and prognosis. Reproductive, pregnancy, and placental exposomes impair the fetal neural exposome through toxic stressor interplay within the MPF triad. Long intervals often separate disease onset from phenotype. Interdisciplinary fetal-neonatal neurology training, practice, and research closes this knowledge gap. Maintaining reproductive health preserves MPF triad health with life-course benefits.
Le texte complet de cet article est disponible en PDF.Keywords : Maternal-placental-fetal triad, Neonatal encephalopathy, Hypoxic-ischemic encephalopathy, Placental disease, Gene-environment interactions, Neural exposome, Social determinants of health
Plan
Vol 51 - N° 3
P. 535-550 - septembre 2024 Retour au numéro
Article précédent
- Causes and Terminology in Neonatal Encephalopathy : What is in a Name? Neonatal Encephalopathy, Hypoxic-ischemic Encephalopathy or Perinatal Asphyxia
- Aoife Branagan, Eleanor J. Molloy, Nadia Badawi, Karin B. Nelson
- Uncovering the Role of Inflammation with Asphyxia in the Newborn
- Simerdeep K. Dhillon, Pierre Gressens, John Barks, Alistair J. Gunn
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